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- W4383556443 abstract "The objective: to evaluate the efficacy and safety of delamanid in a short-course treatment regimen for patients with MDR/pre-XDR pulmonary tuberculosis in Arkhangelsk Region from 2019 to 2021. Subjects and Methods. 32 patients (4 with MDR TB and 28 with pre-XDR TB) started treatment with delamanid within the combination chemotherapy with new drugs, treatment lasted for 12 months. All patients with pre-XDR TB received delamanid, bedaquiline, linezolid, and clofazimine, then the chemotherapy regimen was compiled depending on the clinical situation. Results. Effective treatment was registered in 21/32 patients (65,6%). 4/32 (12,5%) patients interrupted the treatment. Treatment failure was registered in 2/32 (6,25%). During the study, 5 (15,6%) patients died, in none of them tuberculosis was the cause of death. 106 adverse events (AEs) were reported, they included electrolyte imbalance (18,9%), hepatotoxic (16,0%), nephrotoxic (10,4%) and cardiotoxic (10,4%) reactions." @default.
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- W4383556443 date "2023-07-04" @default.
- W4383556443 modified "2023-10-01" @default.
- W4383556443 title "Delamanid in the Treatment of MDR/pre-XDR TB in Arkhangelsk Region in 2019–2021" @default.
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- W4383556443 doi "https://doi.org/10.58838/2075-1230-2023-101-3-62-68" @default.
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