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- W4383556829 abstract "Abstract The need for anticoagulation associated with the use of extracorporeal purification techniques is one of the main concerns regarding these techniques. Although we use sodium heparin (500 IU/h) as the main anticoagulant, we assess the presence of contraindications to it, mainly associated with bleeding risk (thrombocytopenia, coagulopathy). We consider alternatives such as the use of epoprostenol or citrate, or performing EPT without anticoagulation. Furthermore, when repeated hemofilter clotting occurs (>2 sets/day), we consider changing the anticoagulation system, preferably to citrate. While we need to monitor bleeding complications when using heparin or epoprostenol, these complications are minimized with citrate as it is a regional anticoagulation system. In the latter case, we need to monitor for ionic disturbances (mainly hypocalcemia and hypomagnesemia) and electrolyte imbalances (metabolic alkalosis or acidosis due to citrate accumulation) that may occur if adequate monitoring is not carried out." @default.
- W4383556829 created "2023-07-08" @default.
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- W4383556829 date "2023-07-07" @default.
- W4383556829 modified "2023-10-16" @default.
- W4383556829 title "PROTOCOL OF ANTICOAGULATION IN EXTRACORPOREAL PURIFICATION TECHNIQUES" @default.
- W4383556829 doi "https://doi.org/10.21203/rs.3.pex-2236/v1" @default.
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