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- W4383558114 abstract "In socially monogamous prairie voles (Microtus ochrogaster), parental behaviors not only occur in mothers and fathers, but also exist in some virgin males. In contrast, the other virgin males display aggressive behaviors towards conspecific pups. However, little is known about the molecular underpinnings of this behavioral dichotomy, such as gene expression changes and their regulatory mechanisms. To address this, we profiled the transcriptome and DNA methylome of hippocampal dentate gyrus of four prairie vole groups, namely attacker virgin males, parental virgin males, fathers, and mothers. While we found a concordant gene expression pattern between parental virgin males and fathers, the attacker virgin males have a more deviated transcriptome. Moreover, numerous DNA methylation changes were found in pair-wise comparisons among the four groups. We found some DNA methylation changes overlapping with transcription differences, across gene-bodies and promoter regions. Furthermore, the gene expression changes and methylome alterations are selectively enriched in certain biological pathways, such as Wnt signaling, which suggest a canonical transcription regulatory role of DNA methylation in paternal behavior. Therefore, our study presents an integrated view of prairie vole dentate gyrus transcriptome and epigenome that provides a DNA epigenetic based molecular insight of paternal behavior." @default.
- W4383558114 created "2023-07-08" @default.
- W4383558114 creator A5021293751 @default.
- W4383558114 creator A5023229072 @default.
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- W4383558114 creator A5039018479 @default.
- W4383558114 creator A5080144119 @default.
- W4383558114 creator A5085837920 @default.
- W4383558114 date "2023-07-07" @default.
- W4383558114 modified "2023-09-26" @default.
- W4383558114 title "Transcription and DNA methylation signatures of paternal behavior in hippocampal dentate gyrus of prairie voles" @default.
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- W4383558114 doi "https://doi.org/10.1038/s41598-023-37521-2" @default.
- W4383558114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37419920" @default.