FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383558767> ?p ?o ?g. }

• W4383558767 endingPage "102309" @default.
• W4383558767 startingPage "102309" @default.
• W4383558767 abstract "Mesenchymal stem cells (MSC) have been demonstrated to improve cardiac function via the secretion of paracrine factors rather than direct differentiation. We, therefore, investigated whether bone marrow-derived MSC (BMSC)-released exosomes (BMSC-exo) enhance neurological recovery in spontaneously hypertensive rats (SHR) with ischemic stroke. Markers of BMSC and BMSC-exo were detected to characterize BMSC and BMSC-exo. A green fluorescent PKH-67-labeled assay was conducted to ensure BMSC-exo internalization. Rat neuronal cells (RNC) were induced with Ang II and oxygen-glucose deprivation. The protective effects of BMSC-exo on RNC were studied by CCK-8, LDH, and immunofluorescence assays. SHR were subjected to middle cerebral artery occlusion, and the systolic and diastolic blood pressure changes in the modeled rats were measured. The effects of BMSC-exo on SHR were investigated by mNSS scoring, foot-fault tests, immunohistochemistry, Western blot, TTC staining, TUNEL, and HE staining. The hub genes related to SHR and proteins shuttled by BMSC-exo were intersected to obtain a possible candidate, followed by rescue experiments. BMSC-exo significantly promoted RNC viability and repressed cell apoptosis and cytotoxicity. Moreover, SHR administrated with BMSC-exo exhibited significant improvement in functional recovery and narrowed infarct size. BMSC-exo shuttled the MYCBPAP protein. Knockdown of MYCBPAP inhibited the protective effects of BMSC-exo on RNC and exacerbated synaptic damage in SHR. MYCBPAP shuttled by BMSC-exo facilitates synaptic remodeling in SHR, which may contribute to a therapeutic strategy for ischemic stroke treatment." @default.
• W4383558767 created "2023-07-08" @default.
• W4383558767 creator A5028963122 @default.
• W4383558767 creator A5036423556 @default.
• W4383558767 creator A5040330264 @default.
• W4383558767 creator A5085750703 @default.
• W4383558767 date "2023-10-01" @default.
• W4383558767 modified "2023-10-09" @default.
• W4383558767 title "Exosome-shuttled MYCBPAP from bone marrow mesenchymal stem cells regulates synaptic remodeling and ameliorates ischemic stroke in rats" @default.
• W4383558767 cites W2004872316 @default.
• W4383558767 cites W2084346145 @default.
• W4383558767 cites W2096236300 @default.
• W4383558767 cites W2148802014 @default.
• W4383558767 cites W2152546971 @default.
• W4383558767 cites W2168120562 @default.
• W4383558767 cites W2171264103 @default.
• W4383558767 cites W2177788064 @default.
• W4383558767 cites W2338669336 @default.
• W4383558767 cites W2568954699 @default.
• W4383558767 cites W2735733937 @default.
• W4383558767 cites W2736828325 @default.
• W4383558767 cites W2757005172 @default.
• W4383558767 cites W2800500391 @default.
• W4383558767 cites W2892168042 @default.
• W4383558767 cites W2893394744 @default.
• W4383558767 cites W2894454209 @default.
• W4383558767 cites W2900756811 @default.
• W4383558767 cites W2920403041 @default.
• W4383558767 cites W3015209971 @default.
• W4383558767 cites W3036827842 @default.
• W4383558767 cites W3047476089 @default.
• W4383558767 cites W3111888169 @default.
• W4383558767 cites W3154091431 @default.
• W4383558767 cites W3159196121 @default.
• W4383558767 cites W3196967013 @default.
• W4383558767 cites W3209376853 @default.
• W4383558767 cites W4205684676 @default.
• W4383558767 cites W4256175422 @default.
• W4383558767 cites W4282928204 @default.
• W4383558767 cites W4296175720 @default.
• W4383558767 cites W4296995264 @default.
• W4383558767 doi "https://doi.org/10.1016/j.jchemneu.2023.102309" @default.
• W4383558767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37423468" @default.
• W4383558767 hasPublicationYear "2023" @default.
• W4383558767 type Work @default.
• W4383558767 citedByCount "0" @default.
• W4383558767 crossrefType "journal-article" @default.
• W4383558767 hasAuthorship W4383558767A5028963122 @default.
• W4383558767 hasAuthorship W4383558767A5036423556 @default.
• W4383558767 hasAuthorship W4383558767A5040330264 @default.
• W4383558767 hasAuthorship W4383558767A5085750703 @default.
• W4383558767 hasConcept C104317684 @default.
• W4383558767 hasConcept C126322002 @default.
• W4383558767 hasConcept C142724271 @default.
• W4383558767 hasConcept C145059251 @default.
• W4383558767 hasConcept C170493617 @default.
• W4383558767 hasConcept C173396325 @default.
• W4383558767 hasConcept C185592680 @default.
• W4383558767 hasConcept C190283241 @default.
• W4383558767 hasConcept C198826908 @default.
• W4383558767 hasConcept C20518536 @default.
• W4383558767 hasConcept C2776415932 @default.
• W4383558767 hasConcept C2780007613 @default.
• W4383558767 hasConcept C2781261824 @default.
• W4383558767 hasConcept C55493867 @default.
• W4383558767 hasConcept C71924100 @default.
• W4383558767 hasConcept C7876069 @default.
• W4383558767 hasConcept C86803240 @default.
• W4383558767 hasConcept C95444343 @default.
• W4383558767 hasConceptScore W4383558767C104317684 @default.
• W4383558767 hasConceptScore W4383558767C126322002 @default.
• W4383558767 hasConceptScore W4383558767C142724271 @default.
• W4383558767 hasConceptScore W4383558767C145059251 @default.
• W4383558767 hasConceptScore W4383558767C170493617 @default.
• W4383558767 hasConceptScore W4383558767C173396325 @default.
• W4383558767 hasConceptScore W4383558767C185592680 @default.
• W4383558767 hasConceptScore W4383558767C190283241 @default.
• W4383558767 hasConceptScore W4383558767C198826908 @default.
• W4383558767 hasConceptScore W4383558767C20518536 @default.
• W4383558767 hasConceptScore W4383558767C2776415932 @default.
• W4383558767 hasConceptScore W4383558767C2780007613 @default.
• W4383558767 hasConceptScore W4383558767C2781261824 @default.
• W4383558767 hasConceptScore W4383558767C55493867 @default.
• W4383558767 hasConceptScore W4383558767C71924100 @default.
• W4383558767 hasConceptScore W4383558767C7876069 @default.
• W4383558767 hasConceptScore W4383558767C86803240 @default.
• W4383558767 hasConceptScore W4383558767C95444343 @default.
• W4383558767 hasLocation W43835587671 @default.
• W4383558767 hasLocation W43835587672 @default.
• W4383558767 hasOpenAccess W4383558767 @default.
• W4383558767 hasPrimaryLocation W43835587671 @default.
• W4383558767 hasRelatedWork W1970650594 @default.
• W4383558767 hasRelatedWork W2067275497 @default.
• W4383558767 hasRelatedWork W2111545764 @default.
• W4383558767 hasRelatedWork W2529223554 @default.
• W4383558767 hasRelatedWork W2743722047 @default.
• W4383558767 hasRelatedWork W2896759930 @default.
• W4383558767 hasRelatedWork W2947838112 @default.

• next