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- W4383566642 abstract "Poor pharmacokinetic and biopharmaceutical properties are the biggest challenges for newly discovered chemical entities as well as for existing therapeutic molecules. Although conventional formulation development remains a primary strategy for pharmaceutical industries due to its ease of manufacturing. However, these are associated with active pharmaceutical ingredient (API) access to nontargeted tissue/cells, metabolic inactivation, reticuloendothelial system (RES) uptake, low permeability, and bioavailability leading to lower therapeutic efficacy with increased chances of toxicity. In order to counteract such complications related to APIs, there is an urgent need to develop an appropriate drug delivery system that dispenses therapeutic molecules into a specific tissue or organ without any interactions with normal tissue or organs. Targeting is generally achieved via active or passive mechanisms. In passive targeting, the carrier system prolongs residence time and leads to higher bioavailability, whereas active targeting involves the selective binding of drug molecules to receptors of the targeted sites. The targeted drug delivery system is mostly applied for the treatment of cancer, parasite, neurodegenerative, cardiovascular, or infectious diseases. This chapter primarily emphasizes the mechanism and significance of active or passive targeting approaches in drug delivery with their salient features and fundamentals through different routes of administration." @default.
- W4383566642 created "2023-07-08" @default.
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- W4383566642 date "2023-01-01" @default.
- W4383566642 modified "2023-09-27" @default.
- W4383566642 title "Drug delivery: The conceptual perspectives and therapeutic applications" @default.
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- W4383566642 doi "https://doi.org/10.1016/b978-0-323-91663-9.00010-2" @default.
- W4383566642 hasPublicationYear "2023" @default.