Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383567166> ?p ?o ?g. }
- W4383567166 abstract "Prostate cancer is the second most prevalent cancer in men globally. De novo neuroendocrine prostate cancer (NEPC) is uncommon at initial diagnosis, however, (treatment-induced) t-NEPC emerges in up to 25% of prostate adenocarcinoma (PRAD) cases treated with androgen deprivation, carrying a drastically poor prognosis. The transition from PRAD to t-NEPC is underpinned by several key genetic mutations; TP53, RB1, and MYCN are the main genes implicated, bearing similarities to other neuroendocrine tumours. A broad range of epigenetic alterations, such as aberrations in DNA methylation, histone post-translational modifications, and non-coding RNAs, may drive lineage plasticity from PRAD to t-NEPC. The clinical diagnosis of NEPC is hampered by a lack of accessible biomarkers; recent advances in liquid biopsy techniques assessing circulating tumour cells and ctDNA in NEPC suggest that the advent of non-invasive means of monitoring progression to NEPC is on the horizon. Such techniques are vital for NEPC management; diagnosis of t-NEPC is crucial for implementing effective treatment, and precision medicine will be integral to providing the best outcomes for patients." @default.
- W4383567166 created "2023-07-08" @default.
- W4383567166 creator A5009649448 @default.
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- W4383567166 date "2023-01-01" @default.
- W4383567166 modified "2023-09-25" @default.
- W4383567166 title "Genetic and epigenetic features of neuroendocrine prostate cancer and their emerging applications" @default.
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