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- W4383618183 abstract "Abstract Background This study aimed to investigate the expression and clinical significance of Dendritic cell-associated C-type lectin-1 (Dectin-1) in gastric cancer (GC), and to explore the mechanism of Dectin-1 regulating tumour-associated macrophage (TAM)-mediated immune evasion in GC. Methods The association of Dectin-1 + cells with clinical outcomes was inspected by immunohistochemistry on tumour microarrays. Flow cytometry and RNA sequencing were applied to detect characteristics of T cells, phenotypic and transcriptional features of Dectin-1 + TAMs. The effect of Dectin-1 blockade was evaluated using an in vitro intervention experiment based on fresh GC tissues. Results High infiltration of intratumoral Dectin-1 + cells predicted poor prognosis in GC patients. Dectin-1 + cells were mainly composed of TAMs, and the accumulation of Dectin-1 + TAMs was associated with T-cell dysfunction. Notably, Dectin-1 + TAMs exhibited an immunosuppressive phenotype. Furthermore, blockade of Dectin-1 could reprogramme Dectin-1 + TAMs and reactivate anti-tumour effects of T cells, as well as enhanced PD-1 inhibitor-mediated cytotoxicity of CD8 + T cells against tumour cells. Conclusions Dectin-1 could affect T-cell anti-tumour immune response by regulating the immunosuppressive function of TAMs, leading to poor prognosis and immune evasion in GC patients. Blockade of Dectin-1 can be used alone or in combination with current therapeutic strategies in GC." @default.
- W4383618183 created "2023-07-09" @default.
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- W4383618183 date "2023-07-08" @default.
- W4383618183 modified "2023-10-18" @default.
- W4383618183 title "C-type lectin receptor Dectin-1 blockade on tumour-associated macrophages improves anti-PD-1 efficacy in gastric cancer" @default.
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- W4383618183 doi "https://doi.org/10.1038/s41416-023-02336-5" @default.
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