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- W4383618857 endingPage "112152" @default.
- W4383618857 startingPage "112152" @default.
- W4383618857 abstract "Engineered tissue currently lacks requisite capacity to sustain cell viability and functionality. Here we demonstrate that human RPE cell lines (ARPE-19) can be cultured on ultrathin suspended electrospun nanofibre scaffolds (ENS) composed of hydrophobic polymer polyacrylonitrile (PAN) and a water-soluble aliphatic diamine, without (untreated) or with (treated) fluocinolone acetonide (FA). Cells survived and retained their characteristic morphology for up to 150 days with FA-treated ENS and manifested a morphological epithelial phenotype with expression of biomarkers critical for maintaining retinal physiological characteristics. This novel technique for producing culture substrates provides suitable hydrophilicity and a protective environment for prolonged RPE culture and has immense potential for subretinal transplantation. The findings indicate that FA-treated ENS is an excellent matrix for retaining the differentiated and epithelial phenotype." @default.
- W4383618857 created "2023-07-09" @default.
- W4383618857 creator A5006299185 @default.
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- W4383618857 date "2023-08-01" @default.
- W4383618857 modified "2023-09-25" @default.
- W4383618857 title "Retinal pigment epithelial cells can be cultured on fluocinolone acetonide treated nanofibrous scaffold" @default.
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