FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383646335> ?p ?o ?g. }

• W4383646335 endingPage "175906" @default.
• W4383646335 startingPage "175906" @default.
• W4383646335 abstract "and purpose: Interstitial cells of Cajal generate slow wave gastric electrical activity, initiating spontaneous muscle contractions. This becomes dysrhythmic during nausea when [Arg8]-vasopressin (AVP) is also released. In human stomach AVP increased spontaneous contraction activity and muscle tone, not neuronally-mediated contractions. Rodents cannot vomit, releasing the related hormone, oxytocin (OT) instead. We hypothesised that rat stomach would behave differently. Spontaneous and electrically-evoked (EFS) contractions were measured in rat forestomach and antrum circular muscle. Custom software defined spontaneous contractions by analysing eight motility parameters. The forestomach was quiescent. Irregular antrum contractions became regular adjacent to the pylorus (1.7 ± 0.4 mN; 1.2 ± 0.1 contractions/min, n = 12). These were unaffected by tetrodotoxin (10−6 M), atropine (10−6 M) and L-NAME (3 × 10−4 M). In both regions, AVP (pEC50∼9.0) and OT (∼0.5 log10-unit less potent) caused contraction (greater in antrum), competitively antagonized by, respectively, SR49059 (pKB∼9.5) and L371257 (pKB∼9.0), reduced by tetrodotoxin but unaffected by atropine. In the antrum, AVP and OT (∼2 log10-units less potent/efficacious) regularized and increased spontaneous contraction amplitude, frequency, rates of contraction/decay. In both regions, EFS-evoked contractions, abolished by atropine/tetrodotoxin, were reduced by AVP and OT, with AVP more potent and efficacious, particularly in forestomach. Irregular spontaneous contractions of gastric antrum suggest variable ICC-muscle coupling. AVP and less potently, OT, enhanced frequency and force of contractions via V1A and OT receptors. Compared with human, differences in contraction regularity, potency and ability of AVP/OT to affect neuronal function suggests caution when using rat stomach to model ICC functions and nauseagenic stimuli." @default.
• W4383646335 created "2023-07-09" @default.
• W4383646335 creator A5011914921 @default.
• W4383646335 creator A5048726120 @default.
• W4383646335 date "2023-09-01" @default.
• W4383646335 modified "2023-09-27" @default.
• W4383646335 title "Characterization of rat gastric myogenic contractions and modulation by oxytocin and arginine-vasopressin" @default.
• W4383646335 cites W1521868202 @default.
• W4383646335 cites W1566552624 @default.
• W4383646335 cites W1697970968 @default.
• W4383646335 cites W1971150222 @default.
• W4383646335 cites W1973768280 @default.
• W4383646335 cites W1982227541 @default.
• W4383646335 cites W1998637942 @default.
• W4383646335 cites W2004135885 @default.
• W4383646335 cites W2004434133 @default.
• W4383646335 cites W2004512898 @default.
• W4383646335 cites W2005039156 @default.
• W4383646335 cites W2006226430 @default.
• W4383646335 cites W2015380890 @default.
• W4383646335 cites W2027467507 @default.
• W4383646335 cites W2035876098 @default.
• W4383646335 cites W2048333903 @default.
• W4383646335 cites W2055732792 @default.
• W4383646335 cites W2076994104 @default.
• W4383646335 cites W2081459222 @default.
• W4383646335 cites W2088795228 @default.
• W4383646335 cites W2090048009 @default.
• W4383646335 cites W2094295387 @default.
• W4383646335 cites W2156149584 @default.
• W4383646335 cites W2165608965 @default.
• W4383646335 cites W2316617845 @default.
• W4383646335 cites W2418897616 @default.
• W4383646335 cites W2522718901 @default.
• W4383646335 cites W2733991598 @default.
• W4383646335 cites W3105955651 @default.
• W4383646335 cites W3199700588 @default.
• W4383646335 cites W3200892818 @default.
• W4383646335 cites W4229053314 @default.
• W4383646335 cites W4294921110 @default.
• W4383646335 doi "https://doi.org/10.1016/j.ejphar.2023.175906" @default.
• W4383646335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37429518" @default.
• W4383646335 hasPublicationYear "2023" @default.
• W4383646335 type Work @default.
• W4383646335 citedByCount "0" @default.
• W4383646335 crossrefType "journal-article" @default.
• W4383646335 hasAuthorship W4383646335A5011914921 @default.
• W4383646335 hasAuthorship W4383646335A5048726120 @default.
• W4383646335 hasBestOaLocation W43836463351 @default.
• W4383646335 hasConcept C126322002 @default.
• W4383646335 hasConcept C131253125 @default.
• W4383646335 hasConcept C134018914 @default.
• W4383646335 hasConcept C163415756 @default.
• W4383646335 hasConcept C201539569 @default.
• W4383646335 hasConcept C2775859210 @default.
• W4383646335 hasConcept C2776050358 @default.
• W4383646335 hasConcept C2776176026 @default.
• W4383646335 hasConcept C2776370428 @default.
• W4383646335 hasConcept C2776741303 @default.
• W4383646335 hasConcept C2779422922 @default.
• W4383646335 hasConcept C2992686903 @default.
• W4383646335 hasConcept C71924100 @default.
• W4383646335 hasConcept C86803240 @default.
• W4383646335 hasConceptScore W4383646335C126322002 @default.
• W4383646335 hasConceptScore W4383646335C131253125 @default.
• W4383646335 hasConceptScore W4383646335C134018914 @default.
• W4383646335 hasConceptScore W4383646335C163415756 @default.
• W4383646335 hasConceptScore W4383646335C201539569 @default.
• W4383646335 hasConceptScore W4383646335C2775859210 @default.
• W4383646335 hasConceptScore W4383646335C2776050358 @default.
• W4383646335 hasConceptScore W4383646335C2776176026 @default.
• W4383646335 hasConceptScore W4383646335C2776370428 @default.
• W4383646335 hasConceptScore W4383646335C2776741303 @default.
• W4383646335 hasConceptScore W4383646335C2779422922 @default.
• W4383646335 hasConceptScore W4383646335C2992686903 @default.
• W4383646335 hasConceptScore W4383646335C71924100 @default.
• W4383646335 hasConceptScore W4383646335C86803240 @default.
• W4383646335 hasFunder F4320310030 @default.
• W4383646335 hasFunder F4320310465 @default.
• W4383646335 hasLocation W43836463351 @default.
• W4383646335 hasLocation W43836463352 @default.
• W4383646335 hasOpenAccess W4383646335 @default.
• W4383646335 hasPrimaryLocation W43836463351 @default.
• W4383646335 hasRelatedWork W1966654712 @default.
• W4383646335 hasRelatedWork W1984470734 @default.
• W4383646335 hasRelatedWork W2033301635 @default.
• W4383646335 hasRelatedWork W2041552780 @default.
• W4383646335 hasRelatedWork W2069292195 @default.
• W4383646335 hasRelatedWork W2083903426 @default.
• W4383646335 hasRelatedWork W2088618831 @default.
• W4383646335 hasRelatedWork W2326492430 @default.
• W4383646335 hasRelatedWork W4237586391 @default.
• W4383646335 hasRelatedWork W2407537258 @default.
• W4383646335 hasVolume "955" @default.
• W4383646335 isParatext "false" @default.
• W4383646335 isRetracted "false" @default.
• W4383646335 workType "article" @default.