FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383669829> ?p ?o ?g. }

• W4383669829 endingPage "276" @default.
• W4383669829 startingPage "266" @default.
• W4383669829 abstract "Objective: The study is to formulate the enalapril maleate-loaded mucoadhesive microspheres with varied compositions of selected polymers for developing the oral controlled release formulations prepared by ionic gelation method and optimization through central composite design. Methods: Systematic optimization of microspheres was accomplished by the central composite design and characterized for particle size, entrapment efficiency, in vitro drug release and ex vivo mucoadhesion strength, which indicated that microspheres were a consequence to be spherical and free-flowing in nature. The microspheres exhibited high drug entrapment efficiency and in vitro drug release in a sustained manner, which was considered to be dependent on the concentration of rate-controlling polymers. The microspheres are showed 389.2 to 850 µm particle size and 22.36 to 85.22 % encapsulation efficiency. In vitro studies indicated optimized formulation showed 89.26% drug release after 12h and reduced blood pressure effectively. Results: The pharmacokinetic parameters were evaluated with Cmax of 75.39 µg/ml, tmax of 8h, and AUC of 53.55 µg/hr/ml, elimination rate constant of 0.0392 and t1/2 of 10h. The stability studies were conducted for 3 mo under various conditions and identified no significant deviations in selected key quality attributes. Conclusion: The formulated mucoadhesive microspheres of enalapril maleate tend to reduce the blood pressure in the animal model, with the novel drug delivery approach in the efficient management of hypertension." @default.
• W4383669829 created "2023-07-09" @default.
• W4383669829 creator A5000880347 @default.
• W4383669829 creator A5005542183 @default.
• W4383669829 creator A5056545539 @default.
• W4383669829 creator A5087944353 @default.
• W4383669829 date "2023-07-07" @default.
• W4383669829 modified "2023-09-27" @default.
• W4383669829 title "QUALITY BY DESIGN-DRIVEN FORMULATION DEVELOPMENT AND OPTIMIZATION OF ENALAPRIL MALEATE LOADED MUCOADHESIVE MICROSPHERES: IN VITRO AND IN VIVO CHARACTERIZATION" @default.
• W4383669829 cites W1128029328 @default.
• W4383669829 cites W1964790012 @default.
• W4383669829 cites W1986876497 @default.
• W4383669829 cites W1993804396 @default.
• W4383669829 cites W1996220682 @default.
• W4383669829 cites W1996370852 @default.
• W4383669829 cites W2002352354 @default.
• W4383669829 cites W2002926167 @default.
• W4383669829 cites W2038314019 @default.
• W4383669829 cites W2051167097 @default.
• W4383669829 cites W2058912292 @default.
• W4383669829 cites W2071222912 @default.
• W4383669829 cites W2071980979 @default.
• W4383669829 cites W2077250336 @default.
• W4383669829 cites W2083479049 @default.
• W4383669829 cites W2111961347 @default.
• W4383669829 cites W2169339692 @default.
• W4383669829 cites W2181447267 @default.
• W4383669829 cites W2207353195 @default.
• W4383669829 cites W2258939324 @default.
• W4383669829 cites W2324038747 @default.
• W4383669829 cites W2489588489 @default.
• W4383669829 cites W2513735551 @default.
• W4383669829 cites W2613218123 @default.
• W4383669829 cites W2790030594 @default.
• W4383669829 cites W2791283433 @default.
• W4383669829 cites W2810291872 @default.
• W4383669829 cites W4254217015 @default.
• W4383669829 cites W4295154875 @default.
• W4383669829 cites W4324352299 @default.
• W4383669829 cites W4324352327 @default.
• W4383669829 doi "https://doi.org/10.22159/ijap.2023v15i4.47905" @default.
• W4383669829 hasPublicationYear "2023" @default.
• W4383669829 type Work @default.
• W4383669829 citedByCount "0" @default.
• W4383669829 crossrefType "journal-article" @default.
• W4383669829 hasAuthorship W4383669829A5000880347 @default.
• W4383669829 hasAuthorship W4383669829A5005542183 @default.
• W4383669829 hasAuthorship W4383669829A5056545539 @default.
• W4383669829 hasAuthorship W4383669829A5087944353 @default.
• W4383669829 hasBestOaLocation W43836698291 @default.
• W4383669829 hasConcept C112705442 @default.
• W4383669829 hasConcept C126838900 @default.
• W4383669829 hasConcept C127413603 @default.
• W4383669829 hasConcept C13245373 @default.
• W4383669829 hasConcept C136229726 @default.
• W4383669829 hasConcept C147789679 @default.
• W4383669829 hasConcept C150903083 @default.
• W4383669829 hasConcept C178790620 @default.
• W4383669829 hasConcept C185592680 @default.
• W4383669829 hasConcept C187530423 @default.
• W4383669829 hasConcept C189942447 @default.
• W4383669829 hasConcept C207001950 @default.
• W4383669829 hasConcept C22979827 @default.
• W4383669829 hasConcept C27016395 @default.
• W4383669829 hasConcept C2775940317 @default.
• W4383669829 hasConcept C2779820397 @default.
• W4383669829 hasConcept C2780020223 @default.
• W4383669829 hasConcept C42360764 @default.
• W4383669829 hasConcept C43617362 @default.
• W4383669829 hasConcept C71924100 @default.
• W4383669829 hasConcept C84393581 @default.
• W4383669829 hasConcept C86803240 @default.
• W4383669829 hasConcept C98274493 @default.
• W4383669829 hasConceptScore W4383669829C112705442 @default.
• W4383669829 hasConceptScore W4383669829C126838900 @default.
• W4383669829 hasConceptScore W4383669829C127413603 @default.
• W4383669829 hasConceptScore W4383669829C13245373 @default.
• W4383669829 hasConceptScore W4383669829C136229726 @default.
• W4383669829 hasConceptScore W4383669829C147789679 @default.
• W4383669829 hasConceptScore W4383669829C150903083 @default.
• W4383669829 hasConceptScore W4383669829C178790620 @default.
• W4383669829 hasConceptScore W4383669829C185592680 @default.
• W4383669829 hasConceptScore W4383669829C187530423 @default.
• W4383669829 hasConceptScore W4383669829C189942447 @default.
• W4383669829 hasConceptScore W4383669829C207001950 @default.
• W4383669829 hasConceptScore W4383669829C22979827 @default.
• W4383669829 hasConceptScore W4383669829C27016395 @default.
• W4383669829 hasConceptScore W4383669829C2775940317 @default.
• W4383669829 hasConceptScore W4383669829C2779820397 @default.
• W4383669829 hasConceptScore W4383669829C2780020223 @default.
• W4383669829 hasConceptScore W4383669829C42360764 @default.
• W4383669829 hasConceptScore W4383669829C43617362 @default.
• W4383669829 hasConceptScore W4383669829C71924100 @default.
• W4383669829 hasConceptScore W4383669829C84393581 @default.
• W4383669829 hasConceptScore W4383669829C86803240 @default.
• W4383669829 hasConceptScore W4383669829C98274493 @default.
• W4383669829 hasLocation W43836698291 @default.
• W4383669829 hasOpenAccess W4383669829 @default.

• next