Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383669893> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4383669893 endingPage "295" @default.
- W4383669893 startingPage "291" @default.
- W4383669893 abstract "Objective: To estimate plasma concentrations-time profiles of metronidazole commercial tablets through in vitro dissolution data using the Inverse Release Function approach and a convolution method. Methods: Dissolution profiles of metronidazole reference tablets (500 mg) were obtained using USP Apparatus 1 at 100 rpm, USP Apparatus 4 at 16 ml/min, and 0.1 N HCl, pH 4.5 acetate buffer and pH 6.8 phosphate buffer as dissolution media. Additionally, three generic drug products were tested using USP Apparatus 1 and pH 4.5 acetate buffer. Drug was quantified at 278 nm until 60 min. Dissolution parameters such as mean dissolution time, area under the cumulative dissolution curve, and dissolution efficiency were calculated. Metronidazole plasma levels were predicted considering the in vitro release data and published information. Percent of prediction error (PE) for Cmax and AUC0-inf at each condition was calculated. Results: When comparing dissolution profiles with common dissolution parameters (USP 1 vs. 4) significant differences were found (*P<0.05). Values of PE for Cmax and AUC0-inf were within range (±15%) only with USP Apparatus 1 and pH 4.5 acetate buffer. Using these conditions when comparing generic drug products vs. reference formulation, significant differences were found (*P<0.05) and values of PE for AUC0-inf were out of the range. Conclusion: The obtained information suggests using USP Apparatus 1 and pH 4.5 acetate buffer to predict the in vivo performance of metronidazole tablets. The impact of in vitro differences of all generic formulations was confirmed with differences in predicted in vivo performance." @default.
- W4383669893 created "2023-07-09" @default.
- W4383669893 creator A5014615806 @default.
- W4383669893 creator A5029822305 @default.
- W4383669893 creator A5070388054 @default.
- W4383669893 creator A5092431162 @default.
- W4383669893 creator A5092431163 @default.
- W4383669893 creator A5092431164 @default.
- W4383669893 date "2023-07-07" @default.
- W4383669893 modified "2023-09-25" @default.
- W4383669893 title "ESTIMATION OF IN VITRO AND IN VIVO PERFORMANCE OF METRONIDAZOLE ORAL DOSAGE FORMS" @default.
- W4383669893 cites W1963486780 @default.
- W4383669893 cites W1968706872 @default.
- W4383669893 cites W1969682850 @default.
- W4383669893 cites W1981764872 @default.
- W4383669893 cites W1986222251 @default.
- W4383669893 cites W1995634417 @default.
- W4383669893 cites W1997523656 @default.
- W4383669893 cites W2045879423 @default.
- W4383669893 cites W2055080006 @default.
- W4383669893 cites W2063909696 @default.
- W4383669893 cites W2067415149 @default.
- W4383669893 cites W2159374908 @default.
- W4383669893 cites W2327670864 @default.
- W4383669893 cites W2739100735 @default.
- W4383669893 cites W2884271330 @default.
- W4383669893 cites W2889543708 @default.
- W4383669893 cites W3096510416 @default.
- W4383669893 cites W4285734751 @default.
- W4383669893 doi "https://doi.org/10.22159/ijap.2023v15i4.48137" @default.
- W4383669893 hasPublicationYear "2023" @default.
- W4383669893 type Work @default.
- W4383669893 citedByCount "0" @default.
- W4383669893 crossrefType "journal-article" @default.
- W4383669893 hasAuthorship W4383669893A5014615806 @default.
- W4383669893 hasAuthorship W4383669893A5029822305 @default.
- W4383669893 hasAuthorship W4383669893A5070388054 @default.
- W4383669893 hasAuthorship W4383669893A5092431162 @default.
- W4383669893 hasAuthorship W4383669893A5092431163 @default.
- W4383669893 hasAuthorship W4383669893A5092431164 @default.
- W4383669893 hasBestOaLocation W43836698931 @default.
- W4383669893 hasConcept C112705442 @default.
- W4383669893 hasConcept C150903083 @default.
- W4383669893 hasConcept C178790620 @default.
- W4383669893 hasConcept C185592680 @default.
- W4383669893 hasConcept C207001950 @default.
- W4383669893 hasConcept C22979827 @default.
- W4383669893 hasConcept C2777396551 @default.
- W4383669893 hasConcept C2778117296 @default.
- W4383669893 hasConcept C43617362 @default.
- W4383669893 hasConcept C501593827 @default.
- W4383669893 hasConcept C55493867 @default.
- W4383669893 hasConcept C71924100 @default.
- W4383669893 hasConcept C77281830 @default.
- W4383669893 hasConcept C86803240 @default.
- W4383669893 hasConcept C88380143 @default.
- W4383669893 hasConcept C96616956 @default.
- W4383669893 hasConcept C98274493 @default.
- W4383669893 hasConceptScore W4383669893C112705442 @default.
- W4383669893 hasConceptScore W4383669893C150903083 @default.
- W4383669893 hasConceptScore W4383669893C178790620 @default.
- W4383669893 hasConceptScore W4383669893C185592680 @default.
- W4383669893 hasConceptScore W4383669893C207001950 @default.
- W4383669893 hasConceptScore W4383669893C22979827 @default.
- W4383669893 hasConceptScore W4383669893C2777396551 @default.
- W4383669893 hasConceptScore W4383669893C2778117296 @default.
- W4383669893 hasConceptScore W4383669893C43617362 @default.
- W4383669893 hasConceptScore W4383669893C501593827 @default.
- W4383669893 hasConceptScore W4383669893C55493867 @default.
- W4383669893 hasConceptScore W4383669893C71924100 @default.
- W4383669893 hasConceptScore W4383669893C77281830 @default.
- W4383669893 hasConceptScore W4383669893C86803240 @default.
- W4383669893 hasConceptScore W4383669893C88380143 @default.
- W4383669893 hasConceptScore W4383669893C96616956 @default.
- W4383669893 hasConceptScore W4383669893C98274493 @default.
- W4383669893 hasLocation W43836698931 @default.
- W4383669893 hasOpenAccess W4383669893 @default.
- W4383669893 hasPrimaryLocation W43836698931 @default.
- W4383669893 hasRelatedWork W1984506996 @default.
- W4383669893 hasRelatedWork W2034282422 @default.
- W4383669893 hasRelatedWork W2034817623 @default.
- W4383669893 hasRelatedWork W2286601460 @default.
- W4383669893 hasRelatedWork W2306417566 @default.
- W4383669893 hasRelatedWork W2368704086 @default.
- W4383669893 hasRelatedWork W2372948535 @default.
- W4383669893 hasRelatedWork W2379766255 @default.
- W4383669893 hasRelatedWork W2382828870 @default.
- W4383669893 hasRelatedWork W3177561793 @default.
- W4383669893 isParatext "false" @default.
- W4383669893 isRetracted "false" @default.
- W4383669893 workType "article" @default.