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- W4383682593 abstract "Abstract Carboxysomes are protein microcompartments that function in the bacterial CO 2 concentrating mechanism (CCM) to facilitate CO 2 assimilation. To do so, carboxysomes assemble from thousands of constituent proteins into an icosahedral shell which encapsulates the enzymes rubisco and carbonic anhydrase to form structures typically >100 nm and >300 megadaltons. Although many of the protein interactions driving the assembly process have been determined, it remains unknown how size and composition are precisely controlled. Here we show that the size of α-carboxysomes is controlled by the disordered scaffolding protein CsoS2. CsoS2 contains two classes of related peptide repeats which bind to the shell in a distinct fashion, and our data indicate that size is controlled by the relative number of these interactions. We propose an energetic and structural model wherein the two repeat classes bind at the junction of shell hexamers but differ in their preferences for the shell contact angles, and thus the local curvature. In total, this model suggests that a set of specific and repeated interactions between CsoS2 and shell proteins collectively achieve the large size and monodispersity of α-carboxysomes." @default.
- W4383682593 created "2023-07-10" @default.
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- W4383682593 date "2023-07-08" @default.
- W4383682593 modified "2023-09-25" @default.
- W4383682593 title "α-carboxysome size is controlled by the disordered scaffold protein CsoS2" @default.
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- W4383682593 doi "https://doi.org/10.1101/2023.07.07.548173" @default.
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