Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383695470> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4383695470 abstract "Immune checkpoint inhibitors (ICIs) are the standard treatment for metastatic colorectal cancer (mCRC) with high microsatellite instability (MSI-H). Among immune-related adverse events (irAEs), drug-induced sarcoidosis-like reactions (DISR) are often difficult to differentiate from cancer progression.This is a case of a woman in her mid-60s, with mCRC (RAS wild/BRAF mutant/MSI-H) and abdominal lymph node metastasis, treated with four courses of ipilimumab + nivolumab every 3 weeks, followed by nivolumab every 2 weeks as third-line treatment. After treatment, the original lymph node metastases shrank, but hilar/mediastinal lymph nodes appeared. Endoscopic ultrasound-guided fine-needle aspiration of these lymph nodes revealed multiple epithelioid granulomas without necrosis, indicating a sarcoidosis-like reaction. Fluorodeoxyglucose-positron emission tomography scan showed abnormal subcutaneous accumulation in bilateral forearms and bilateral knee joints. Biopsy of the cutaneous lesions was also performed, which revealed epithelioid granulomas. As the patient had no symptoms in other organs, no specific therapeutic intervention was administered. After the discontinuation of immunotherapy, the sarcoidosis-like reaction regressed without cancer relapse.Clinicians should be aware of the possibility of DISR as an irAE during the ICI treatment of mCRC. In suspected cases of DISR following ICI therapy, it is important to differentiate between cancer progression and DISR through histological diagnosis for the subsequent strategy, as radiological and serological findings are not definitive." @default.
- W4383695470 created "2023-07-10" @default.
- W4383695470 creator A5004324897 @default.
- W4383695470 creator A5006474560 @default.
- W4383695470 creator A5016728036 @default.
- W4383695470 creator A5021158752 @default.
- W4383695470 creator A5029787595 @default.
- W4383695470 creator A5030298726 @default.
- W4383695470 creator A5042912300 @default.
- W4383695470 creator A5047518504 @default.
- W4383695470 creator A5052282410 @default.
- W4383695470 creator A5061794485 @default.
- W4383695470 creator A5064684165 @default.
- W4383695470 creator A5076509316 @default.
- W4383695470 creator A5084113589 @default.
- W4383695470 creator A5090795865 @default.
- W4383695470 date "2023-07-10" @default.
- W4383695470 modified "2023-09-26" @default.
- W4383695470 title "Hilar/mediastinal and cutaneous drug-induced sarcoidosis-like reaction associated with immune checkpoint inhibitors in metastatic colorectal cancer: a case report" @default.
- W4383695470 cites W2069032581 @default.
- W4383695470 cites W2098205979 @default.
- W4383695470 cites W2122096722 @default.
- W4383695470 cites W2137712039 @default.
- W4383695470 cites W2265285917 @default.
- W4383695470 cites W2673218446 @default.
- W4383695470 cites W2782484253 @default.
- W4383695470 cites W2796327298 @default.
- W4383695470 cites W2799401120 @default.
- W4383695470 cites W2800727262 @default.
- W4383695470 cites W2988124258 @default.
- W4383695470 cites W3014719302 @default.
- W4383695470 cites W3173561643 @default.
- W4383695470 cites W3190537829 @default.
- W4383695470 doi "https://doi.org/10.3389/fimmu.2023.1203621" @default.
- W4383695470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37492584" @default.
- W4383695470 hasPublicationYear "2023" @default.
- W4383695470 type Work @default.
- W4383695470 citedByCount "1" @default.
- W4383695470 countsByYear W43836954702023 @default.
- W4383695470 crossrefType "journal-article" @default.
- W4383695470 hasAuthorship W4383695470A5004324897 @default.
- W4383695470 hasAuthorship W4383695470A5006474560 @default.
- W4383695470 hasAuthorship W4383695470A5016728036 @default.
- W4383695470 hasAuthorship W4383695470A5021158752 @default.
- W4383695470 hasAuthorship W4383695470A5029787595 @default.
- W4383695470 hasAuthorship W4383695470A5030298726 @default.
- W4383695470 hasAuthorship W4383695470A5042912300 @default.
- W4383695470 hasAuthorship W4383695470A5047518504 @default.
- W4383695470 hasAuthorship W4383695470A5052282410 @default.
- W4383695470 hasAuthorship W4383695470A5061794485 @default.
- W4383695470 hasAuthorship W4383695470A5064684165 @default.
- W4383695470 hasAuthorship W4383695470A5076509316 @default.
- W4383695470 hasAuthorship W4383695470A5084113589 @default.
- W4383695470 hasAuthorship W4383695470A5090795865 @default.
- W4383695470 hasBestOaLocation W43836954701 @default.
- W4383695470 hasConcept C121608353 @default.
- W4383695470 hasConcept C126322002 @default.
- W4383695470 hasConcept C142724271 @default.
- W4383695470 hasConcept C143998085 @default.
- W4383695470 hasConcept C2777658100 @default.
- W4383695470 hasConcept C2777701055 @default.
- W4383695470 hasConcept C2780030458 @default.
- W4383695470 hasConcept C2780849966 @default.
- W4383695470 hasConcept C2781301800 @default.
- W4383695470 hasConcept C2781433595 @default.
- W4383695470 hasConcept C502942594 @default.
- W4383695470 hasConcept C526805850 @default.
- W4383695470 hasConcept C71924100 @default.
- W4383695470 hasConceptScore W4383695470C121608353 @default.
- W4383695470 hasConceptScore W4383695470C126322002 @default.
- W4383695470 hasConceptScore W4383695470C142724271 @default.
- W4383695470 hasConceptScore W4383695470C143998085 @default.
- W4383695470 hasConceptScore W4383695470C2777658100 @default.
- W4383695470 hasConceptScore W4383695470C2777701055 @default.
- W4383695470 hasConceptScore W4383695470C2780030458 @default.
- W4383695470 hasConceptScore W4383695470C2780849966 @default.
- W4383695470 hasConceptScore W4383695470C2781301800 @default.
- W4383695470 hasConceptScore W4383695470C2781433595 @default.
- W4383695470 hasConceptScore W4383695470C502942594 @default.
- W4383695470 hasConceptScore W4383695470C526805850 @default.
- W4383695470 hasConceptScore W4383695470C71924100 @default.
- W4383695470 hasLocation W43836954701 @default.
- W4383695470 hasLocation W43836954702 @default.
- W4383695470 hasLocation W43836954703 @default.
- W4383695470 hasOpenAccess W4383695470 @default.
- W4383695470 hasPrimaryLocation W43836954701 @default.
- W4383695470 hasRelatedWork W2155654588 @default.
- W4383695470 hasRelatedWork W2745358348 @default.
- W4383695470 hasRelatedWork W2770760027 @default.
- W4383695470 hasRelatedWork W2773756552 @default.
- W4383695470 hasRelatedWork W2888298425 @default.
- W4383695470 hasRelatedWork W2947988614 @default.
- W4383695470 hasRelatedWork W2955428297 @default.
- W4383695470 hasRelatedWork W2963333658 @default.
- W4383695470 hasRelatedWork W2969687411 @default.
- W4383695470 hasRelatedWork W4361939003 @default.
- W4383695470 hasVolume "14" @default.
- W4383695470 isParatext "false" @default.
- W4383695470 isRetracted "false" @default.
- W4383695470 workType "article" @default.