Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383709904> ?p ?o ?g. }
- W4383709904 abstract "Hyperinflammation elicited by lipopolysaccharide (LPS) that derives from multidrug-resistant Gram-negative pathogens, leads to a sharp increase in mortality globally. However, monotherapies aiming to neutralize LPS often fail to improve the prognosis. Here, an all-in-one drug delivery strategy equipped with bactericidal activity, LPS neutralization, and detoxification is shown to recognize, kill pathogens, and attenuate hyperinflammation by abolishing the activation of LPS-triggered acute inflammatory responses. First, bactericidal colistin results in rapid bacterial killing, and the released LPS is subsequently sequestered. The neutralized LPS is further cleared by acyloxyacyl hydrolase to remove secondary fatty chains and detoxify LPS in situ. Last, such a system shows high efficacy in two mouse infection models challenged with Pseudomonas aeruginosa. This approach integrates direct antibacterial activity with in situ LPS neutralizing and detoxifying properties, shedding light on the development of alternative interventions to treat sepsis-associated infections." @default.
- W4383709904 created "2023-07-11" @default.
- W4383709904 creator A5023036987 @default.
- W4383709904 creator A5049033166 @default.
- W4383709904 creator A5082020327 @default.
- W4383709904 creator A5085765662 @default.
- W4383709904 creator A5087755674 @default.
- W4383709904 creator A5089313542 @default.
- W4383709904 date "2023-07-10" @default.
- W4383709904 modified "2023-10-01" @default.
- W4383709904 title "In Situ Neutralization and Detoxification of LPS to Attenuate Hyperinflammation" @default.
- W4383709904 cites W1648631879 @default.
- W4383709904 cites W1858567345 @default.
- W4383709904 cites W1978508787 @default.
- W4383709904 cites W1991209345 @default.
- W4383709904 cites W1993303218 @default.
- W4383709904 cites W2010701664 @default.
- W4383709904 cites W2048164478 @default.
- W4383709904 cites W2051101891 @default.
- W4383709904 cites W2064400743 @default.
- W4383709904 cites W2071159951 @default.
- W4383709904 cites W2093355099 @default.
- W4383709904 cites W2113532250 @default.
- W4383709904 cites W2124755314 @default.
- W4383709904 cites W2127934565 @default.
- W4383709904 cites W2128664082 @default.
- W4383709904 cites W2130655121 @default.
- W4383709904 cites W2134408956 @default.
- W4383709904 cites W2145889332 @default.
- W4383709904 cites W2179036997 @default.
- W4383709904 cites W2179359515 @default.
- W4383709904 cites W2345407464 @default.
- W4383709904 cites W2396212074 @default.
- W4383709904 cites W2617620062 @default.
- W4383709904 cites W2625057882 @default.
- W4383709904 cites W2782495818 @default.
- W4383709904 cites W2782754655 @default.
- W4383709904 cites W2791550160 @default.
- W4383709904 cites W2808829764 @default.
- W4383709904 cites W2947835267 @default.
- W4383709904 cites W2953427954 @default.
- W4383709904 cites W2962926163 @default.
- W4383709904 cites W2966130344 @default.
- W4383709904 cites W2985968951 @default.
- W4383709904 cites W2987333527 @default.
- W4383709904 cites W2995170042 @default.
- W4383709904 cites W3020336784 @default.
- W4383709904 cites W3022981886 @default.
- W4383709904 cites W3024354797 @default.
- W4383709904 cites W3039517954 @default.
- W4383709904 cites W3039707154 @default.
- W4383709904 cites W3043837506 @default.
- W4383709904 cites W3087463662 @default.
- W4383709904 cites W3087617819 @default.
- W4383709904 cites W3126673609 @default.
- W4383709904 cites W3128260795 @default.
- W4383709904 cites W3136688190 @default.
- W4383709904 cites W3154323133 @default.
- W4383709904 cites W3175089144 @default.
- W4383709904 cites W3187055239 @default.
- W4383709904 cites W3194841544 @default.
- W4383709904 cites W3195841364 @default.
- W4383709904 cites W4234317413 @default.
- W4383709904 cites W4309245207 @default.
- W4383709904 cites W4383709904 @default.
- W4383709904 doi "https://doi.org/10.1002/advs.202302950" @default.
- W4383709904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37428467" @default.
- W4383709904 hasPublicationYear "2023" @default.
- W4383709904 type Work @default.
- W4383709904 citedByCount "1" @default.
- W4383709904 countsByYear W43837099042023 @default.
- W4383709904 crossrefType "journal-article" @default.
- W4383709904 hasAuthorship W4383709904A5023036987 @default.
- W4383709904 hasAuthorship W4383709904A5049033166 @default.
- W4383709904 hasAuthorship W4383709904A5082020327 @default.
- W4383709904 hasAuthorship W4383709904A5085765662 @default.
- W4383709904 hasAuthorship W4383709904A5087755674 @default.
- W4383709904 hasAuthorship W4383709904A5089313542 @default.
- W4383709904 hasBestOaLocation W43837099041 @default.
- W4383709904 hasConcept C14086860 @default.
- W4383709904 hasConcept C142724271 @default.
- W4383709904 hasConcept C159654299 @default.
- W4383709904 hasConcept C185592680 @default.
- W4383709904 hasConcept C19702531 @default.
- W4383709904 hasConcept C203014093 @default.
- W4383709904 hasConcept C204787440 @default.
- W4383709904 hasConcept C2777637488 @default.
- W4383709904 hasConcept C2778384902 @default.
- W4383709904 hasConcept C2778754761 @default.
- W4383709904 hasConcept C2779259085 @default.
- W4383709904 hasConcept C2780497538 @default.
- W4383709904 hasConcept C501593827 @default.
- W4383709904 hasConcept C523546767 @default.
- W4383709904 hasConcept C54355233 @default.
- W4383709904 hasConcept C71924100 @default.
- W4383709904 hasConcept C86803240 @default.
- W4383709904 hasConcept C89423630 @default.
- W4383709904 hasConcept C98274493 @default.
- W4383709904 hasConceptScore W4383709904C14086860 @default.
- W4383709904 hasConceptScore W4383709904C142724271 @default.