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- W4383710131 abstract "Abstract Until recently, clinicians and researchers did not realize paternal exposures could impact child developmental outcomes. Indeed, although there is growing recognition that sperm carry a large amount of non‐genomic information and that paternal stressors influence the health of the next generation, toxicologists are only now beginning to explore the role paternal exposures have in dysgenesis and the incidence of congenital malformations. In this commentary, I will briefly summarize the few studies describing congenital malformations resulting from preconception paternal stressors, argue for the theoretical expansion of teratogenic perspectives into the male preconception period, and discuss some of the challenges in this newly emerging branch of toxicology. I argue that we must consider gametes the same as any other malleable precursor cell type and recognize that environmentally‐induced epigenetic changes acquired during the formation of the sperm and oocyte hold equal teratogenic potential as exposures during early development. Here, I propose the term epiteratogen to reference agents acting outside of pregnancy that, through epigenetic mechanisms, induce congenital malformations. Understanding the interactions between the environment, the essential epigenetic processes intrinsic to spermatogenesis, and their cumulative influences on embryo patterning is essential to addressing a significant blind spot in the field of developmental toxicology." @default.
- W4383710131 created "2023-07-11" @default.
- W4383710131 creator A5074863991 @default.
- W4383710131 date "2023-07-09" @default.
- W4383710131 modified "2023-10-17" @default.
- W4383710131 title "Teratogenesis and the epigenetic programming of congenital defects: Why paternal exposures matter" @default.
- W4383710131 cites W1526516695 @default.
- W4383710131 cites W1576493923 @default.
- W4383710131 cites W1587143425 @default.
- W4383710131 cites W1949928978 @default.
- W4383710131 cites W1967064280 @default.
- W4383710131 cites W1976110788 @default.
- W4383710131 cites W1976684529 @default.
- W4383710131 cites W1996381562 @default.
- W4383710131 cites W1997522925 @default.
- W4383710131 cites W2026175834 @default.
- W4383710131 cites W2033589672 @default.
- W4383710131 cites W2036300762 @default.
- W4383710131 cites W2036402097 @default.
- W4383710131 cites W2044794679 @default.
- W4383710131 cites W2055237453 @default.
- W4383710131 cites W2055681612 @default.
- W4383710131 cites W2059632047 @default.
- W4383710131 cites W2064415230 @default.
- W4383710131 cites W2069713835 @default.
- W4383710131 cites W2072491205 @default.
- W4383710131 cites W2073122969 @default.
- W4383710131 cites W2073823475 @default.
- W4383710131 cites W2074300285 @default.
- W4383710131 cites W2075805514 @default.
- W4383710131 cites W2085207628 @default.
- W4383710131 cites W2096989726 @default.
- W4383710131 cites W2098926940 @default.
- W4383710131 cites W2099680166 @default.
- W4383710131 cites W2101037833 @default.
- W4383710131 cites W2118024649 @default.
- W4383710131 cites W2137291580 @default.
- W4383710131 cites W2140795328 @default.
- W4383710131 cites W2147977360 @default.
- W4383710131 cites W2150073394 @default.
- W4383710131 cites W2152343110 @default.
- W4383710131 cites W2168212194 @default.
- W4383710131 cites W2170807763 @default.
- W4383710131 cites W2175849508 @default.
- W4383710131 cites W2203634181 @default.
- W4383710131 cites W2209353711 @default.
- W4383710131 cites W2210080033 @default.
- W4383710131 cites W2217449599 @default.
- W4383710131 cites W2234491466 @default.
- W4383710131 cites W2287198619 @default.
- W4383710131 cites W2409262378 @default.
- W4383710131 cites W2490531610 @default.
- W4383710131 cites W2528415436 @default.
- W4383710131 cites W2572270804 @default.
- W4383710131 cites W2578988291 @default.
- W4383710131 cites W2614778000 @default.
- W4383710131 cites W2617423748 @default.
- W4383710131 cites W2619988375 @default.
- W4383710131 cites W2626966407 @default.
- W4383710131 cites W2747465281 @default.
- W4383710131 cites W2762001107 @default.
- W4383710131 cites W2769587159 @default.
- W4383710131 cites W2783884366 @default.
- W4383710131 cites W2787931223 @default.
- W4383710131 cites W2788260464 @default.
- W4383710131 cites W2798760795 @default.
- W4383710131 cites W2812975072 @default.
- W4383710131 cites W2885557879 @default.
- W4383710131 cites W2888850090 @default.
- W4383710131 cites W2899868920 @default.
- W4383710131 cites W2902372981 @default.
- W4383710131 cites W2903418331 @default.
- W4383710131 cites W2908571759 @default.
- W4383710131 cites W2918899876 @default.
- W4383710131 cites W2943765663 @default.
- W4383710131 cites W2943984669 @default.
- W4383710131 cites W2945015074 @default.
- W4383710131 cites W2963537251 @default.
- W4383710131 cites W2977851778 @default.
- W4383710131 cites W2978347397 @default.
- W4383710131 cites W2979933334 @default.
- W4383710131 cites W2989900837 @default.
- W4383710131 cites W3010644311 @default.
- W4383710131 cites W3010930521 @default.
- W4383710131 cites W3011142704 @default.
- W4383710131 cites W3012402207 @default.
- W4383710131 cites W3025558388 @default.
- W4383710131 cites W3045697927 @default.
- W4383710131 cites W3085604246 @default.
- W4383710131 cites W3086506816 @default.
- W4383710131 cites W3105808047 @default.
- W4383710131 cites W3129727715 @default.
- W4383710131 cites W3140337708 @default.
- W4383710131 cites W3154702379 @default.
- W4383710131 cites W3198958002 @default.
- W4383710131 cites W3216459040 @default.
- W4383710131 cites W4210255007 @default.
- W4383710131 cites W4220951607 @default.
- W4383710131 cites W4220956838 @default.
- W4383710131 cites W4281481439 @default.