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- W4383710320 abstract "Resource10 July 2023 Transparent process Single-cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment Guangxu Cao Guangxu Cao orcid.org/0000-0002-2159-5459 Department of Obstetrics and Gynecology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China Contribution: Resources, Validation, Investigation, Visualization, Methodology, Writing - original draft, Writing - review & editing Search for more papers by this author Jiali Yue Jiali Yue orcid.org/0000-0002-3754-2343 Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, Tongji Hospital, Frontier Science Center for Stem Cells, School of Life Science and Technology, Tongji University, Shanghai, China Contribution: Software, Investigation, Visualization, Methodology, Writing - original draft Search for more papers by this author Yetian Ruan Yetian Ruan orcid.org/0000-0001-7888-2734 Department of Obstetrics and Gynecology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China Contribution: Investigation Search for more papers by this author Ya Han Ya Han Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, Tongji Hospital, Frontier Science Center for Stem Cells, School of Life Science and Technology, Tongji University, Shanghai, China Contribution: Software, Investigation, Methodology Search for more papers by this author Yong Zhi Yong Zhi Department of Obstetrics and Gynecology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China Contribution: Investigation, Visualization Search for more papers by this author Jianqiao Lu Jianqiao Lu Department of Obstetrics and Gynecology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China Contribution: Investigation Search for more papers by this author Min Liu Min Liu orcid.org/0000-0001-6095-3469 Department of Obstetrics and Gynecology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China Contribution: Investigation Search for more papers by this author Xinxin Xu Xinxin Xu Department of Obstetrics and Gynecology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China Contribution: Investigation Search for more papers by this author Jin Wang Jin Wang Department of Obstetrics and Gynecology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China Contribution: Writing - review & editing Search for more papers by this author Quan Gu Quan Gu orcid.org/0000-0002-1201-6734 CVR Bioinformatics, University of Glasgow Centre for Virus Research, Glasgow, UK Contribution: Investigation, Writing - review & editing Search for more papers by this author Xuejun Wen Xuejun Wen Department of Chemical and Life Science Engineering, School of Engineering, Virginia Commonwealth University, Richmond, Virginia, USA Contribution: Supervision Search for more papers by this author Jinli Gao Jinli Gao Department of Pathology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China Contribution: Investigation, Methodology Search for more papers by this author Qingfeng Zhang Qingfeng Zhang orcid.org/0000-0002-8759-9102 Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, Tongji Hospital, Frontier Science Center for Stem Cells, School of Life Science and Technology, Tongji University, Shanghai, China Contribution: Supervision, Writing - review & editing Search for more papers by this author Jiuhong Kang Jiuhong Kang orcid.org/0000-0001-7538-1889 Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, Collaborative Innovation Center for Brain Science, School of Life Sciences and Technology, Tongji University, Shanghai, China Contribution: Writing - review & editing Search for more papers by this author Chenfei Wang Corresponding Author Chenfei Wang [email protected] orcid.org/0000-0001-7573-3768 Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, Tongji Hospital, Frontier Science Center for Stem Cells, School of Life Science and Technology, Tongji University, Shanghai, China Contribution: Conceptualization, Data curation, Software, Formal analysis, Supervision, Funding acquisition, Project administration Search for more papers by this author Fang Li Corresponding Author Fang Li [email protected] orcid.org/0000-0003-0342-3941 Department of Obstetrics and Gynecology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China Contribution: Conceptualization, Resources, Data curation, Supervision, Funding acquisition, Project administration Search for more papers by this author Guangxu Cao Guangxu Cao orcid.org/0000-0002-2159-5459 Department of Obstetrics and Gynecology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China Contribution: Resources, Validation, Investigation, Visualization, Methodology, Writing - original draft, Writing - review & editing Search for more papers by this author Jiali Yue Jiali Yue orcid.org/0000-0002-3754-2343 Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, Tongji Hospital, Frontier Science Center for Stem Cells, School of Life Science and Technology, Tongji University, Shanghai, China Contribution: Software, Investigation, Visualization, Methodology, Writing - original draft Search for more papers by this author Yetian Ruan Yetian Ruan orcid.org/0000-0001-7888-2734 Department of Obstetrics and Gynecology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China Contribution: Investigation Search for more papers by this author Ya Han Ya Han Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, Tongji Hospital, Frontier Science Center for Stem Cells, School of Life Science and Technology, Tongji University, Shanghai, China Contribution: Software, Investigation, Methodology Search for more papers by this author Yong Zhi Yong Zhi Department of Obstetrics and Gynecology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China Contribution: Investigation, Visualization Search for more papers by this author Jianqiao Lu Jianqiao Lu Department of Obstetrics and Gynecology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China Contribution: Investigation Search for more papers by this author Min Liu Min Liu orcid.org/0000-0001-6095-3469 Department of Obstetrics and Gynecology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China Contribution: Investigation Search for more papers by this author Xinxin Xu Xinxin Xu Department of Obstetrics and Gynecology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China Contribution: Investigation Search for more papers by this author Jin Wang Jin Wang Department of Obstetrics and Gynecology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China Contribution: Writing - review & editing Search for more papers by this author Quan Gu Quan Gu orcid.org/0000-0002-1201-6734 CVR Bioinformatics, University of Glasgow Centre for Virus Research, Glasgow, UK Contribution: Investigation, Writing - review & editing Search for more papers by this author Xuejun Wen Xuejun Wen Department of Chemical and Life Science Engineering, School of Engineering, Virginia Commonwealth University, Richmond, Virginia, USA Contribution: Supervision Search for more papers by this author Jinli Gao Jinli Gao Department of Pathology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China Contribution: Investigation, Methodology Search for more papers by this author Qingfeng Zhang Qingfeng Zhang orcid.org/0000-0002-8759-9102 Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, Tongji Hospital, Frontier Science Center for Stem Cells, School of Life Science and Technology, Tongji University, Shanghai, China Contribution: Supervision, Writing - review & editing Search for more papers by this author Jiuhong Kang Jiuhong Kang orcid.org/0000-0001-7538-1889 Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, Collaborative Innovation Center for Brain Science, School of Life Sciences and Technology, Tongji University, Shanghai, China Contribution: Writing - review & editing Search for more papers by this author Chenfei Wang Corresponding Author Chenfei Wang [email protected] orcid.org/0000-0001-7573-3768 Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, Tongji Hospital, Frontier Science Center for Stem Cells, School of Life Science and Technology, Tongji University, Shanghai, China Contribution: Conceptualization, Data curation, Software, Formal analysis, Supervision, Funding acquisition, Project administration Search for more papers by this author Fang Li Corresponding Author Fang Li [email protected] orcid.org/0000-0003-0342-3941 Department of Obstetrics and Gynecology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China Contribution: Conceptualization, Resources, Data curation, Supervision, Funding acquisition, Project administration Search for more papers by this author Author Information Guangxu Cao1,†, Jiali Yue2,†, Yetian Ruan1,†, Ya Han2, Yong Zhi1, Jianqiao Lu1, Min Liu1, Xinxin Xu1, Jin Wang1, Quan Gu3, Xuejun Wen4, Jinli Gao5, Qingfeng Zhang2, Jiuhong Kang6, Chenfei Wang *,2 and Fang Li *,1 1Department of Obstetrics and Gynecology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China 2Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopedics, Tongji Hospital, Frontier Science Center for Stem Cells, School of Life Science and Technology, Tongji University, Shanghai, China 3CVR Bioinformatics, University of Glasgow Centre for Virus Research, Glasgow, UK 4Department of Chemical and Life Science Engineering, School of Engineering, Virginia Commonwealth University, Richmond, Virginia, USA 5Department of Pathology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China 6Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, Collaborative Innovation Center for Brain Science, School of Life Sciences and Technology, Tongji University, Shanghai, China † These authors contributed equally to this work *Corresponding author. Tel: +86 21 65981195; E-mail: [email protected] *Corresponding author. Tel: +86 21 38804518 31027; E-mail: [email protected] The EMBO Journal (2023)e110757https://doi.org/10.15252/embj.2022110757 Full textView the full text of the articlePDFDownload PDF of article text and main figures.PDF PLUSDownload PDF of article text, main figures, expanded view figures and appendix. Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions Figures & Info Abstract The tumor microenvironment (TME) directly determines patients' outcomes and therapeutic efficiencies. An in-depth understanding of the TME is required to improve the prognosis of patients with cervical cancer (CC). This study conducted single-cell RNA and TCR sequencing of six-paired tumors and adjacent normal tissues to map the CC immune landscape. T and NK cells were highly enriched in the tumor area and transitioned from cytotoxic to exhaustion phenotypes. Our analyses suggest that cytotoxic large-clone T cells are critical effectors in the antitumor response. This study also revealed tumor-specific germinal center B cells associated with tertiary lymphoid structures. A high-germinal center B cell proportion in patients with CC is predictive of improved clinical outcomes and is associated with elevated hormonal immune responses. We depicted an immune-excluded stromal landscape and established a joint model of tumor and stromal cells to predict CC patients' prognosis. The study revealed tumor ecosystem subsets linked to antitumor response or prognosis in the TME and provides information for future combinational immunotherapy. Synopsis Single-cell level evaluation of the composition of malignant, immune, and stromal cells in the tumor microenvironment of cervical cancer (CC) determines critical subsets of immune response and prognosis. Single-cell and immune repertoire analysis of CC and adjacent normal tissue highlights critical immune and stromal clusters. T cells are mostly exhausted in CC, while large clones are more prone to cytotoxic immune responses. The presence of tertiary lymphoid structures and germinal center response in CC tumors links to B-cell–mediated anti-tumor response. Co-occurrence analysis of epithelial and stromal subsets provides a promising prognostic model for patients with CC. Previous ArticleNext Article Read MoreAbout the coverClose modalView large imageVolume 0,Issue 0,This cover highlights the article NALCN-mediated sodium influx confers metastatic prostate cancer cell invasiveness by Antoine Folcher, Dmitri Gordienko, Oksana Iamshanova, Natalia Prevarskaya and colleagues. Sustained Na+ influx via the sodium leak channel (NALCN) in aggressive prostate cancer cells recruits plasma membrane and mitochondrial Na+/Ca2+ exchangers, Ca2+ pumps and Ca2+-permeable ion channels to generate long-lasting Ca2+ oscillations. These, in turn, condition Src-regulated actin remodeling, Ca2+-dependent secretion of proteolytic enzymes and invadopodia formation, thus increasing cancer cell invasiveness. (Scientific image by Dmitri Gordienko, University of Lille, France) Latest OnlineView all ReferencesRelatedDetailsLoading ..." @default.
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- W4383710320 title "Single‐cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment" @default.
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