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• W4383710365 abstract "The zebrafishZebrafish model has been used in many different fields of research because of its high homology to the human genome, its easy genetic manipulation, its high fecundity, and its rapid development. For glomerular diseasesGlomerular diseases, zebrafishZebrafish larvae have proven to be a versatile tool to study the contribution of different genes, because the zebrafishZebrafish pronephros is very comparable to the human kidney in function and ultrastructure. Here we describe the principle and use of a simple screening assay based on the measurement of the fluorescence in the retinal vessel plexus of the Tg(l-fabp:DBP:eGFP) zebrafishZebrafish line (“eye assay”) to indirectly determine proteinuriaProteinuria as a hallmark of podocyte dysfunction. Furthermore, we illustrate how to analyze the obtained data and outline methods to attribute the findings to podocyte impairment." @default.
• W4383710365 created "2023-07-11" @default.
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• W4383710365 date "2023-01-01" @default.
• W4383710365 modified "2023-09-24" @default.
• W4383710365 title "Zebrafish Model to Study Podocyte Function Within the Glomerular Filtration Barrier" @default.
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• W4383710365 doi "https://doi.org/10.1007/978-1-0716-3179-9_11" @default.
• W4383710365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37423988" @default.
• W4383710365 hasPublicationYear "2023" @default.
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