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• W4383710825 endingPage "9355" @default.
• W4383710825 startingPage "9337" @default.
• W4383710825 abstract "Two prominent cytoplasmic RNA granules, ubiquitous RNA-processing bodies (PB) and inducible stress granules (SG), regulate mRNA translation and are intimately related. In this study, we found that arsenite (ARS)-induced SG formed in a stepwise process is topologically and mechanically linked to PB. Two essential PB components, GW182 and DDX6, are repurposed under stress to play direct but distinguishable roles in SG biogenesis. By providing scaffolding activities, GW182 promotes the aggregation of SG components to form SG bodies. DEAD-box helicase DDX6 is also essential for the proper assembly and separation of PB from SG. DDX6 deficiency results in the formation of irregularly shaped 'hybrid' PB/SG granules with accumulated components of both PB and SG. Wild-type DDX6, but not its helicase mutant E247A, can rescue the separation of PB from SG in DDX6KO cells, indicating a requirement of DDX6 helicase activity for this process. DDX6 activity in biogenesis of both PB and SG in the cells under stress is further modulated by its interaction with two protein partners, CNOT1 and 4E-T, of which knockdown affects the formation of both PB and also SG. Together, these data highlight a new functional paradigm between PB and SG biogenesis during the stress." @default.
• W4383710825 created "2023-07-11" @default.
• W4383710825 creator A5003170920 @default.
• W4383710825 creator A5027184681 @default.
• W4383710825 creator A5061205525 @default.
• W4383710825 creator A5086610984 @default.
• W4383710825 date "2023-07-10" @default.
• W4383710825 modified "2023-09-27" @default.
• W4383710825 title "RNA helicase DDX6 and scaffold protein GW182 in P-bodies promote biogenesis of stress granules" @default.
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