Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383710854> ?p ?o ?g. }
- W4383710854 endingPage "9250" @default.
- W4383710854 startingPage "9229" @default.
- W4383710854 abstract "Lipid metabolism disorder is closely related to metabolic diseases, inflammation, and cancer. The concentration of citrate in the cytosol has a significant impact on lipid synthesis. The expression of citrate transporters (SLC13A5 and SLC25A1) and metabolic enzymes (ACLY) proves to be substantially raised in various diseases related to disorders of lipid metabolism, such as hyperlipemia, nonalcoholic fatty liver disease, and prostate cancer. Targeting key proteins in the citrate transport and metabolic pathways is considered an effective strategy for treating various metabolic diseases. However, there is currently only one ACLY inhibitor approved for marketing, and no SLC13A5 inhibitor has entered clinical research. Further development of drugs targeting citrate transport and metabolism is needed for the treatment of metabolic diseases. This perspective summarizes the biological role, therapeutic potential, and research progress of citrate transport and metabolism and then discusses the achievements and prospects of modulators targeting citrate transport and metabolism for therapeutic applications." @default.
- W4383710854 created "2023-07-11" @default.
- W4383710854 creator A5018588998 @default.
- W4383710854 creator A5060844115 @default.
- W4383710854 creator A5068190679 @default.
- W4383710854 creator A5073332881 @default.
- W4383710854 creator A5087138635 @default.
- W4383710854 date "2023-07-10" @default.
- W4383710854 modified "2023-10-10" @default.
- W4383710854 title "Opportunities and Challenges for Inhibitors Targeting Citrate Transport and Metabolism in Drug Discovery" @default.
- W4383710854 cites W111603817 @default.
- W4383710854 cites W1136751452 @default.
- W4383710854 cites W1530265295 @default.
- W4383710854 cites W1531638822 @default.
- W4383710854 cites W1656913045 @default.
- W4383710854 cites W1715970343 @default.
- W4383710854 cites W180430440 @default.
- W4383710854 cites W1857663964 @default.
- W4383710854 cites W1876771593 @default.
- W4383710854 cites W1884221296 @default.
- W4383710854 cites W1967188028 @default.
- W4383710854 cites W1967206613 @default.
- W4383710854 cites W1973054593 @default.
- W4383710854 cites W1973137063 @default.
- W4383710854 cites W1975566288 @default.
- W4383710854 cites W1978294917 @default.
- W4383710854 cites W1980568044 @default.
- W4383710854 cites W1986797467 @default.
- W4383710854 cites W1990276200 @default.
- W4383710854 cites W1992490718 @default.
- W4383710854 cites W1993234914 @default.
- W4383710854 cites W1995251646 @default.
- W4383710854 cites W1998166655 @default.
- W4383710854 cites W2003863419 @default.
- W4383710854 cites W2010696845 @default.
- W4383710854 cites W2011265174 @default.
- W4383710854 cites W2020110583 @default.
- W4383710854 cites W2022201565 @default.
- W4383710854 cites W2025378773 @default.
- W4383710854 cites W2028874440 @default.
- W4383710854 cites W2031182339 @default.
- W4383710854 cites W2032443341 @default.
- W4383710854 cites W2033347797 @default.
- W4383710854 cites W2038514978 @default.
- W4383710854 cites W2041405746 @default.
- W4383710854 cites W2044515618 @default.
- W4383710854 cites W2045926990 @default.
- W4383710854 cites W2047738369 @default.
- W4383710854 cites W2052584789 @default.
- W4383710854 cites W2052964746 @default.
- W4383710854 cites W2053179984 @default.
- W4383710854 cites W2054800464 @default.
- W4383710854 cites W2056780561 @default.
- W4383710854 cites W2059300250 @default.
- W4383710854 cites W2060408030 @default.
- W4383710854 cites W2061199004 @default.
- W4383710854 cites W2062439849 @default.
- W4383710854 cites W2063673863 @default.
- W4383710854 cites W2065261177 @default.
- W4383710854 cites W2068372246 @default.
- W4383710854 cites W2069386055 @default.
- W4383710854 cites W2069775190 @default.
- W4383710854 cites W2075560763 @default.
- W4383710854 cites W2080349528 @default.
- W4383710854 cites W2085536106 @default.
- W4383710854 cites W2086546138 @default.
- W4383710854 cites W2108846738 @default.
- W4383710854 cites W2109920062 @default.
- W4383710854 cites W2116501341 @default.
- W4383710854 cites W2117644277 @default.
- W4383710854 cites W2131406107 @default.
- W4383710854 cites W2134285011 @default.
- W4383710854 cites W2137083729 @default.
- W4383710854 cites W2138709778 @default.
- W4383710854 cites W2144575277 @default.
- W4383710854 cites W2151216008 @default.
- W4383710854 cites W2157936931 @default.
- W4383710854 cites W2161970758 @default.
- W4383710854 cites W2164359822 @default.
- W4383710854 cites W2165409643 @default.
- W4383710854 cites W2167753201 @default.
- W4383710854 cites W2169626949 @default.
- W4383710854 cites W2169983443 @default.
- W4383710854 cites W2170640967 @default.
- W4383710854 cites W2186613797 @default.
- W4383710854 cites W2230299152 @default.
- W4383710854 cites W2234115940 @default.
- W4383710854 cites W2260653927 @default.
- W4383710854 cites W2265709850 @default.
- W4383710854 cites W2409605687 @default.
- W4383710854 cites W2503851771 @default.
- W4383710854 cites W2515237216 @default.
- W4383710854 cites W2554717001 @default.
- W4383710854 cites W2558403885 @default.
- W4383710854 cites W2558991743 @default.
- W4383710854 cites W2568968070 @default.
- W4383710854 cites W2581380146 @default.
- W4383710854 cites W2587680743 @default.