Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383711210> ?p ?o ?g. }
- W4383711210 abstract "2D cell culture occupies an important place in cancer progression and drug discovery research. However, it limitedly models the “true biology” of tumors in vivo. 3D tumor culture systems can better mimic tumor characteristics for anticancer drug discovery but still maintain great challenges. Herein, polydopamine (PDA)-modified decellularized lung scaffolds are designed and can serve as a functional biosystem to study tumor progression and anticancer drug screening, as well as mimic the tumor microenvironment. PDA-modified scaffolds with strong hydrophilicity and excellent cell compatibility can promote cell growth and proliferation. After 96 h treatment with 5-FU, cisplatin, and DOX, higher survival rates in PDA-modified scaffolds are observed compared to nonmodified scaffolds and 2D systems. The E-cadhesion formation, HIF-1α-mediated senescence decrease, and tumor stemness enhancement can drive drug resistance and antitumor drug screening of breast cancer cells. Moreover, there is a higher survival rate of CD45+/CD3+/CD4+/CD8+ T cells in PDA-modified scaffolds for potential cancer immunotherapy drug screening. This PDA-modified tumor bioplatform will supply some promising information for studying tumor progression, overcoming tumor resistance, and screening tumor immunotherapy drugs." @default.
- W4383711210 created "2023-07-11" @default.
- W4383711210 creator A5022537085 @default.
- W4383711210 creator A5027569325 @default.
- W4383711210 creator A5029607765 @default.
- W4383711210 creator A5053747969 @default.
- W4383711210 creator A5056120792 @default.
- W4383711210 creator A5060588206 @default.
- W4383711210 creator A5076480096 @default.
- W4383711210 date "2023-07-09" @default.
- W4383711210 modified "2023-10-17" @default.
- W4383711210 title "A PDA‐Functionalized 3D Lung Scaffold Bioplatform to Construct Complicated Breast Tumor Microenvironment for Anticancer Drug Screening and Immunotherapy" @default.
- W4383711210 cites W1935095490 @default.
- W4383711210 cites W1973970463 @default.
- W4383711210 cites W1986507956 @default.
- W4383711210 cites W1990418094 @default.
- W4383711210 cites W1996833161 @default.
- W4383711210 cites W2001112532 @default.
- W4383711210 cites W2008757142 @default.
- W4383711210 cites W2009734791 @default.
- W4383711210 cites W2012495753 @default.
- W4383711210 cites W2014964804 @default.
- W4383711210 cites W2015149841 @default.
- W4383711210 cites W2016235191 @default.
- W4383711210 cites W2017985800 @default.
- W4383711210 cites W2022030273 @default.
- W4383711210 cites W2027518405 @default.
- W4383711210 cites W2028243583 @default.
- W4383711210 cites W2035955364 @default.
- W4383711210 cites W2038238523 @default.
- W4383711210 cites W2050875646 @default.
- W4383711210 cites W2065815553 @default.
- W4383711210 cites W2094454542 @default.
- W4383711210 cites W2123232388 @default.
- W4383711210 cites W2145341441 @default.
- W4383711210 cites W2145470537 @default.
- W4383711210 cites W2153817817 @default.
- W4383711210 cites W2209812019 @default.
- W4383711210 cites W2328886593 @default.
- W4383711210 cites W2623029422 @default.
- W4383711210 cites W2735127852 @default.
- W4383711210 cites W2749380379 @default.
- W4383711210 cites W2765175699 @default.
- W4383711210 cites W2788009719 @default.
- W4383711210 cites W2795152388 @default.
- W4383711210 cites W2806296092 @default.
- W4383711210 cites W2896243932 @default.
- W4383711210 cites W2902786538 @default.
- W4383711210 cites W2926981293 @default.
- W4383711210 cites W2952660336 @default.
- W4383711210 cites W2966465234 @default.
- W4383711210 cites W2981470547 @default.
- W4383711210 cites W2996862224 @default.
- W4383711210 cites W3016152430 @default.
- W4383711210 cites W3045724696 @default.
- W4383711210 cites W3049719712 @default.
- W4383711210 cites W3109557787 @default.
- W4383711210 cites W3128493312 @default.
- W4383711210 cites W3133961417 @default.
- W4383711210 cites W3134727590 @default.
- W4383711210 cites W3164049919 @default.
- W4383711210 cites W3173932077 @default.
- W4383711210 cites W3214744876 @default.
- W4383711210 cites W4205458395 @default.
- W4383711210 cites W4206386811 @default.
- W4383711210 cites W4213293797 @default.
- W4383711210 cites W4233790125 @default.
- W4383711210 cites W4281384920 @default.
- W4383711210 cites W4281878748 @default.
- W4383711210 cites W4309905300 @default.
- W4383711210 cites W4310346608 @default.
- W4383711210 cites W4383711210 @default.
- W4383711210 doi "https://doi.org/10.1002/advs.202302855" @default.
- W4383711210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37424037" @default.
- W4383711210 hasPublicationYear "2023" @default.
- W4383711210 type Work @default.
- W4383711210 citedByCount "2" @default.
- W4383711210 countsByYear W43837112102023 @default.
- W4383711210 crossrefType "journal-article" @default.
- W4383711210 hasAuthorship W4383711210A5022537085 @default.
- W4383711210 hasAuthorship W4383711210A5027569325 @default.
- W4383711210 hasAuthorship W4383711210A5029607765 @default.
- W4383711210 hasAuthorship W4383711210A5053747969 @default.
- W4383711210 hasAuthorship W4383711210A5056120792 @default.
- W4383711210 hasAuthorship W4383711210A5060588206 @default.
- W4383711210 hasAuthorship W4383711210A5076480096 @default.
- W4383711210 hasBestOaLocation W43837112101 @default.
- W4383711210 hasConcept C114851261 @default.
- W4383711210 hasConcept C121608353 @default.
- W4383711210 hasConcept C126322002 @default.
- W4383711210 hasConcept C150903083 @default.
- W4383711210 hasConcept C167672396 @default.
- W4383711210 hasConcept C203014093 @default.
- W4383711210 hasConcept C207001950 @default.
- W4383711210 hasConcept C2776107976 @default.
- W4383711210 hasConcept C2777701055 @default.
- W4383711210 hasConcept C2780035454 @default.
- W4383711210 hasConcept C3020616263 @default.
- W4383711210 hasConcept C502942594 @default.
- W4383711210 hasConcept C71924100 @default.