FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383711224> ?p ?o ?g. }

• W4383711224 endingPage "926" @default.
• W4383711224 startingPage "919" @default.
• W4383711224 abstract "In this study, the impact of thiamine (Thi), N-acetyl cysteine (NAC), and dexamethasone (DEX) were investigated in axotomized rats, as a model for neural injury.Sixty-five axotomized rats were divided into two different experimental approaches, the first experiments included five study groups (n=5): intrathecal Thi (Thi.it), intraperitoneal (Thi), NAC, DEX, and control. Cell survival was assessed in L5DRG in the 4th week by histological assessment. In the second study, 40 animals were engaged to assess Bcl-2, Bax, IL-6, and TNF-α expression in L4-L5DRG in the 1st and 2nd weeks after sural nerve axotomy under treatment of these agents (n=10).Ghost cells were observed in morphological assessment of L5DRG sections, and following stereological analysis, the volume and neuronal cell counts significantly were improved in the NAC and Thi.it groups in the 4th week (P<0.05). Although Bcl-2 expression did not show significant differences, Bax was reduced in the Thi group (P=0.01); and the Bcl-2/Bax ratio increased in the NAC group (1st week, P<0.01). Furthermore, the IL-6 and TNF-α expression decreased in the Thi and NAC groups, on the 1st week of treatment (P≤0.05 and P<0.01). However, in the 2nd week, the IL-6 expression in both Thi and NAC groups (P<0.01), and the TNF-α expression in the DEX group (P=0.05) were significantly decreased.The findings may classify Thi in the category of peripheral neuroprotective agents, in combination with routine medications. Furthermore, it had strong cell survival effects as it could interfere with the destructive effects of TNF-α by increasing Bax." @default.
• W4383711224 created "2023-07-11" @default.
• W4383711224 creator A5000231575 @default.
• W4383711224 creator A5027442091 @default.
• W4383711224 creator A5042000835 @default.
• W4383711224 creator A5045541890 @default.
• W4383711224 creator A5074061145 @default.
• W4383711224 date "2023-01-01" @default.
• W4383711224 modified "2023-10-16" @default.
• W4383711224 title "Thiamine as a peripheral neuro-protective agent in comparison with N-acetyl cysteine in axotomized rats." @default.
• W4383711224 cites W111265872 @default.
• W4383711224 cites W1220658840 @default.
• W4383711224 cites W1540436551 @default.
• W4383711224 cites W1646647792 @default.
• W4383711224 cites W1676039051 @default.
• W4383711224 cites W1916800927 @default.
• W4383711224 cites W1965357024 @default.
• W4383711224 cites W1972592953 @default.
• W4383711224 cites W1974380002 @default.
• W4383711224 cites W1980745289 @default.
• W4383711224 cites W1982324570 @default.
• W4383711224 cites W1989337759 @default.
• W4383711224 cites W1991993617 @default.
• W4383711224 cites W1992047131 @default.
• W4383711224 cites W1992637526 @default.
• W4383711224 cites W2000381211 @default.
• W4383711224 cites W2004013719 @default.
• W4383711224 cites W2006193913 @default.
• W4383711224 cites W2006286340 @default.
• W4383711224 cites W2015542500 @default.
• W4383711224 cites W2024858865 @default.
• W4383711224 cites W2027906747 @default.
• W4383711224 cites W2031822167 @default.
• W4383711224 cites W2049893910 @default.
• W4383711224 cites W2050834877 @default.
• W4383711224 cites W2066304974 @default.
• W4383711224 cites W2075498662 @default.
• W4383711224 cites W2083663966 @default.
• W4383711224 cites W2084038253 @default.
• W4383711224 cites W2086407395 @default.
• W4383711224 cites W2089430125 @default.
• W4383711224 cites W2089640591 @default.
• W4383711224 cites W2090822573 @default.
• W4383711224 cites W2113891054 @default.
• W4383711224 cites W2116356198 @default.
• W4383711224 cites W2117351537 @default.
• W4383711224 cites W2119351082 @default.
• W4383711224 cites W2128241170 @default.
• W4383711224 cites W2137845912 @default.
• W4383711224 cites W2138909102 @default.
• W4383711224 cites W2141178052 @default.
• W4383711224 cites W2145630514 @default.
• W4383711224 cites W2150623659 @default.
• W4383711224 cites W2153521635 @default.
• W4383711224 cites W2154471766 @default.
• W4383711224 cites W2163837621 @default.
• W4383711224 cites W2169881523 @default.
• W4383711224 cites W2276418388 @default.
• W4383711224 cites W2325615207 @default.
• W4383711224 cites W2409247412 @default.
• W4383711224 cites W2593746293 @default.
• W4383711224 cites W2905805130 @default.
• W4383711224 cites W2912343418 @default.
• W4383711224 cites W2927973673 @default.
• W4383711224 doi "https://doi.org/10.22038/ijbms.2023.67157.14726" @default.
• W4383711224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37427326" @default.
• W4383711224 hasPublicationYear "2023" @default.
• W4383711224 type Work @default.
• W4383711224 citedByCount "0" @default.
• W4383711224 crossrefType "journal-article" @default.
• W4383711224 hasAuthorship W4383711224A5000231575 @default.
• W4383711224 hasAuthorship W4383711224A5027442091 @default.
• W4383711224 hasAuthorship W4383711224A5042000835 @default.
• W4383711224 hasAuthorship W4383711224A5045541890 @default.
• W4383711224 hasAuthorship W4383711224A5074061145 @default.
• W4383711224 hasConcept C126322002 @default.
• W4383711224 hasConcept C17991360 @default.
• W4383711224 hasConcept C25498285 @default.
• W4383711224 hasConcept C2776203871 @default.
• W4383711224 hasConcept C2779683492 @default.
• W4383711224 hasConcept C2780401358 @default.
• W4383711224 hasConcept C42219234 @default.
• W4383711224 hasConcept C529278444 @default.
• W4383711224 hasConcept C71924100 @default.
• W4383711224 hasConcept C98274493 @default.
• W4383711224 hasConceptScore W4383711224C126322002 @default.
• W4383711224 hasConceptScore W4383711224C17991360 @default.
• W4383711224 hasConceptScore W4383711224C25498285 @default.
• W4383711224 hasConceptScore W4383711224C2776203871 @default.
• W4383711224 hasConceptScore W4383711224C2779683492 @default.
• W4383711224 hasConceptScore W4383711224C2780401358 @default.
• W4383711224 hasConceptScore W4383711224C42219234 @default.
• W4383711224 hasConceptScore W4383711224C529278444 @default.
• W4383711224 hasConceptScore W4383711224C71924100 @default.
• W4383711224 hasConceptScore W4383711224C98274493 @default.
• W4383711224 hasIssue "8" @default.
• W4383711224 hasLocation W43837112241 @default.
• W4383711224 hasOpenAccess W4383711224 @default.

• next