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- W4383711232 abstract "The functional unit of human kidney is the nephron. This structure is composed of a glomerulus, connected to a tubule that drains into a collecting duct. The cells which make up the glomerulus are critically important to the appropriate function of this specialised structure. Damage to glomerular cells, particularly the podocytes, is the primary cause of numerous kidney diseases. However, access to and the subsequent culture of human glomerular cells is limited. As such, the ability to generate human glomerular cell types from induced pluripotent stem cells (iPSCs) at scale has garnered great interest. Here, we describe a method to isolate, culture and study 3D human glomeruli from induced pluripotent stem cell (iPSC)-derived kidney organoids in vitro. These 3D glomeruli retain appropriate transcriptional profiles and can be generated from any individual. As isolated glomeruli, they have applicability for disease modelling and drug discovery." @default.
- W4383711232 created "2023-07-11" @default.
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- W4383711232 date "2023-01-01" @default.
- W4383711232 modified "2023-09-26" @default.
- W4383711232 title "Generating Human Glomeruli from Pluripotent Stem Cells for Disease Modelling and Drug Screening" @default.
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- W4383711232 doi "https://doi.org/10.1007/978-1-0716-3179-9_5" @default.
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- W4383711232 hasPublicationYear "2023" @default.
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