FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383711259> ?p ?o ?g. }

• W4383711259 endingPage "4020" @default.
• W4383711259 startingPage "4007" @default.
• W4383711259 abstract "Distant metastasis of malignant tumors is considered to be the main culprit for the failure of current antitumor treatments. Conventional single treatments often exhibit limited efficacy in inhibiting tumor metastasis. Therefore, there is a growing interest in developing collaborative antitumor strategies based on photothermal therapy (PTT) and free-radical-generated photodynamic therapy (PDT), especially utilizing oxygen-independent nanoplatforms, to address this challenge. Such antitumor strategies can enhance the therapeutic outcomes by ensuring the cytotoxicity of free radicals even in the hypoxic tumor microenvironment, thereby improving the effective suppression of primary tumors. Additionally, these approaches can stimulate the production of tumor-associated antigens and amplify the immunogenic cell death (ICD) effects, potentially feasible for enhancing the therapeutic outcomes of immunotherapy. Herein, we fabricated a functional nanosystem that co-loads IR780 and 2,2'-azobis[2-(2-imidazolin-2-yl)propane]-dihydrochloride (AIPH) to realize PTT-triggered thermodynamic combination therapy via the oxygen-independent pathway for the elimination of primary tumors. Furthermore, the nanocomposites were surface-decorated with a predesigned complex peptide (PLGVRGC-anti-PD-L1 peptide, MMP-sensitive), which facilitated the immunotherapy targeting distant tumors. Through the specific recognition of matrix metalloproteinase (MMP), the sensitive segment on the obtained aNC@IR780A was cleaved. As a result, the freed anti-PD-L1 peptide effectively blocked immune checkpoints, leading to the infiltration and activation of T cells (CTLs). This nanosystem was proven to be effective at inhibiting both primary tumors and distant tumors, providing a promising combination strategy for tumor PTT/TDT/immunotherapy." @default.
• W4383711259 created "2023-07-11" @default.
• W4383711259 creator A5022332332 @default.
• W4383711259 creator A5025661802 @default.
• W4383711259 creator A5031043332 @default.
• W4383711259 creator A5031397999 @default.
• W4383711259 creator A5045737015 @default.
• W4383711259 creator A5047784280 @default.
• W4383711259 creator A5054474107 @default.
• W4383711259 creator A5061557340 @default.
• W4383711259 date "2023-07-10" @default.
• W4383711259 modified "2023-10-06" @default.
• W4383711259 title "PD-L1 Blockade Peptide-Modified Polymeric Nanoparticles for Oxygen-Independent-Based Hypoxic Tumor Photo/Thermodynamic Immunotherapy" @default.
• W4383711259 cites W1909852912 @default.
• W4383711259 cites W2038449477 @default.
• W4383711259 cites W2079018735 @default.
• W4383711259 cites W2129482327 @default.
• W4383711259 cites W2130030995 @default.
• W4383711259 cites W2165838507 @default.
• W4383711259 cites W2260067559 @default.
• W4383711259 cites W2345664901 @default.
• W4383711259 cites W2516126003 @default.
• W4383711259 cites W2529562623 @default.
• W4383711259 cites W2594569109 @default.
• W4383711259 cites W2610182885 @default.
• W4383711259 cites W2615993918 @default.
• W4383711259 cites W2747423355 @default.
• W4383711259 cites W2755360248 @default.
• W4383711259 cites W2791998350 @default.
• W4383711259 cites W2793067479 @default.
• W4383711259 cites W2813804716 @default.
• W4383711259 cites W2900151934 @default.
• W4383711259 cites W2905021023 @default.
• W4383711259 cites W2910400715 @default.
• W4383711259 cites W2913170266 @default.
• W4383711259 cites W2923698402 @default.
• W4383711259 cites W2969282776 @default.
• W4383711259 cites W2979459373 @default.
• W4383711259 cites W2985730015 @default.
• W4383711259 cites W3002639883 @default.
• W4383711259 cites W3082210897 @default.
• W4383711259 cites W3089245402 @default.
• W4383711259 cites W3164054621 @default.
• W4383711259 cites W3179501078 @default.
• W4383711259 cites W3215602861 @default.
• W4383711259 cites W4200304692 @default.
• W4383711259 cites W4211003453 @default.
• W4383711259 cites W4212993306 @default.
• W4383711259 cites W4213136615 @default.
• W4383711259 cites W4221027203 @default.
• W4383711259 cites W4283313568 @default.
• W4383711259 cites W4312019105 @default.
• W4383711259 doi "https://doi.org/10.1021/acs.molpharmaceut.3c00186" @default.
• W4383711259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37427910" @default.
• W4383711259 hasPublicationYear "2023" @default.
• W4383711259 type Work @default.
• W4383711259 citedByCount "0" @default.
• W4383711259 crossrefType "journal-article" @default.
• W4383711259 hasAuthorship W4383711259A5022332332 @default.
• W4383711259 hasAuthorship W4383711259A5025661802 @default.
• W4383711259 hasAuthorship W4383711259A5031043332 @default.
• W4383711259 hasAuthorship W4383711259A5031397999 @default.
• W4383711259 hasAuthorship W4383711259A5045737015 @default.
• W4383711259 hasAuthorship W4383711259A5047784280 @default.
• W4383711259 hasAuthorship W4383711259A5054474107 @default.
• W4383711259 hasAuthorship W4383711259A5061557340 @default.
• W4383711259 hasConcept C121608353 @default.
• W4383711259 hasConcept C126322002 @default.
• W4383711259 hasConcept C171250308 @default.
• W4383711259 hasConcept C178790620 @default.
• W4383711259 hasConcept C182606246 @default.
• W4383711259 hasConcept C185592680 @default.
• W4383711259 hasConcept C192562407 @default.
• W4383711259 hasConcept C203014093 @default.
• W4383711259 hasConcept C2776107976 @default.
• W4383711259 hasConcept C2777701055 @default.
• W4383711259 hasConcept C2777877232 @default.
• W4383711259 hasConcept C2779013556 @default.
• W4383711259 hasConcept C2780674031 @default.
• W4383711259 hasConcept C2781323092 @default.
• W4383711259 hasConcept C3020616263 @default.
• W4383711259 hasConcept C502942594 @default.
• W4383711259 hasConcept C71924100 @default.
• W4383711259 hasConcept C8891405 @default.
• W4383711259 hasConceptScore W4383711259C121608353 @default.
• W4383711259 hasConceptScore W4383711259C126322002 @default.
• W4383711259 hasConceptScore W4383711259C171250308 @default.
• W4383711259 hasConceptScore W4383711259C178790620 @default.
• W4383711259 hasConceptScore W4383711259C182606246 @default.
• W4383711259 hasConceptScore W4383711259C185592680 @default.
• W4383711259 hasConceptScore W4383711259C192562407 @default.
• W4383711259 hasConceptScore W4383711259C203014093 @default.
• W4383711259 hasConceptScore W4383711259C2776107976 @default.
• W4383711259 hasConceptScore W4383711259C2777701055 @default.
• W4383711259 hasConceptScore W4383711259C2777877232 @default.
• W4383711259 hasConceptScore W4383711259C2779013556 @default.
• W4383711259 hasConceptScore W4383711259C2780674031 @default.
• W4383711259 hasConceptScore W4383711259C2781323092 @default.

• next