Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383711281> ?p ?o ?g. }
- W4383711281 abstract "The lateral periaqueductal gray (LPAG), which mainly contains glutamatergic neurons, plays an important role in social responses, pain, and offensive and defensive behaviors. Currently, the whole-brain monosynaptic inputs to LPAG glutamatergic neurons are unknown. This study aims to explore the structural framework of the underlying neural mechanisms of LPAG glutamatergic neurons.This study used retrograde tracing systems based on the rabies virus, Cre-LoxP technology, and immunofluorescence analysis.We found that 59 nuclei projected monosynaptic inputs to the LPAG glutamatergic neurons. In addition, seven hypothalamic nuclei, namely the lateral hypothalamic area (LH), lateral preoptic area (LPO), substantia innominata (SI), medial preoptic area, ventral pallidum, posterior hypothalamic area, and lateral globus pallidus, projected most densely to the LPAG glutamatergic neurons. Notably, we discovered through further immunofluorescence analysis that the inputs to the LPAG glutamatergic neurons were colocalized with several markers related to important neurological functions associated with physiological behaviors.The LPAG glutamatergic neurons received dense projections from the hypothalamus, especially nuclei such as LH, LPO, and SI. The input neurons were colocalized with several markers of physiological behaviors, which show the pivotal role of glutamatergic neurons in the physiological behaviors regulation by LPAG." @default.
- W4383711281 created "2023-07-11" @default.
- W4383711281 creator A5003759585 @default.
- W4383711281 creator A5004717630 @default.
- W4383711281 creator A5058439988 @default.
- W4383711281 creator A5067071053 @default.
- W4383711281 creator A5067733392 @default.
- W4383711281 creator A5074817377 @default.
- W4383711281 creator A5082779969 @default.
- W4383711281 date "2023-07-09" @default.
- W4383711281 modified "2023-10-17" @default.
- W4383711281 title "Whole‐brain monosynaptic inputs to lateral periaqueductal gray glutamatergic neurons in mice" @default.
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