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- W4383711299 abstract "Abstract Multidrug efflux systems of the resistance‐nodulation‐cell division family play a crucial role in resistance of Pseudomonas aeruginosa to a large variety of antibiotics. Here, we investigated the role of clinically relevant efflux pumps MexAB − OprM, MexCD − OprJ, and MexXY − OprM in resistance against different cationic antimicrobial peptides (AMPs). Our results indicate that a knock‐out in efflux pump MexXY‐OprM increased susceptibility to some AMPs by two‐ to eightfold. Our data suggest a contribution of MexXY‐OprM in resistance to certain AMPs in P. aeruginosa , which should be considered in the future development of new and highly active antimicrobial peptides to fight multidrug resistant infections." @default.
- W4383711299 created "2023-07-11" @default.
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- W4383711299 date "2023-07-09" @default.
- W4383711299 modified "2023-09-26" @default.
- W4383711299 title "Knock‐out of multidrug efflux pump MexXY‐OprM results in increased susceptibility to antimicrobial peptides in <i>Pseudomonas aeruginosa</i>" @default.
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- W4383711299 doi "https://doi.org/10.1111/1348-0421.13089" @default.
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