Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383720712> ?p ?o ?g. }
- W4383720712 abstract "Serum thyroglobulin (Tg) is a highly sensitive and specific tumor marker, employed in post-operative management of patients with differentiated thyroid carcinomas. Tumor shrinkage of radioiodine-refractory thyroid cancer (RAIR-DTC) treated with multitarget kinase inhibitors as lenvatinib, expressed according to the Response Evaluation Criteria in Solid Tumors (RECIST), is also associated with a drastic reduction of Tg levels. However, interference caused by circulating thyroglobulin autoantibodies (TgAb) represents the main limitation in the clinical use of Tg.To evaluate if in RAIR-DTC TgAb could be considered a surrogate marker of Tg in monitoring response to treatment with lenvatinib.We retrospectively evaluated patients who had started lenvatinib and correlated serum Tg and TgAb with the radiological response across visits.University of Pisa, Italy.We selected 9/97 RAIR-DTC patients with detectable TgAb.None.None.Tg values correlated neither with TgAb title nor with radiological response across visits. Greater decreases in TgAb titer correlated with favorable radiological response to lenvatinib after 1 month (Spearman's correlation = 0.74, P = .021) and 6 months (correlation = 0.61, P = .079). According to RECIST, patients with partial response showed a ∼10-fold greater decrease in TgAb compared to those with stable disease at 1 month (median TgAb decrease: -142 vs -14 IU/mL, P = .01) and those with progressive disease at 6 months (median TgAb decrease: -264 vs-24 IU/mL, P = .04).TgAb evaluation may represent a reliable surrogate marker for Tg trend in evaluating response of RAIR-DTC to treatment with lenvatinib. A multicentric study would be useful to confirm our results." @default.
- W4383720712 created "2023-07-11" @default.
- W4383720712 creator A5007551001 @default.
- W4383720712 creator A5020949961 @default.
- W4383720712 creator A5028070004 @default.
- W4383720712 creator A5030712568 @default.
- W4383720712 creator A5031834824 @default.
- W4383720712 creator A5031919664 @default.
- W4383720712 creator A5057692962 @default.
- W4383720712 creator A5062419704 @default.
- W4383720712 creator A5064525257 @default.
- W4383720712 creator A5069952259 @default.
- W4383720712 date "2023-07-03" @default.
- W4383720712 modified "2023-09-24" @default.
- W4383720712 title "Significance of thyroglobulin autoantibodies in patients with thyroid cancer treated with lenvatinib" @default.
- W4383720712 cites W1966602367 @default.
- W4383720712 cites W1967792499 @default.
- W4383720712 cites W1978885181 @default.
- W4383720712 cites W1984273763 @default.
- W4383720712 cites W2006398749 @default.
- W4383720712 cites W2014433399 @default.
- W4383720712 cites W2019607817 @default.
- W4383720712 cites W2045197681 @default.
- W4383720712 cites W2046215409 @default.
- W4383720712 cites W2067095180 @default.
- W4383720712 cites W2070220790 @default.
- W4383720712 cites W2072114559 @default.
- W4383720712 cites W2087293168 @default.
- W4383720712 cites W2095036778 @default.
- W4383720712 cites W2105004316 @default.
- W4383720712 cites W2116549502 @default.
- W4383720712 cites W2126365735 @default.
- W4383720712 cites W2143527243 @default.
- W4383720712 cites W2145150141 @default.
- W4383720712 cites W2145240320 @default.
- W4383720712 cites W2156045312 @default.
- W4383720712 cites W2156961356 @default.
- W4383720712 cites W2163175491 @default.
- W4383720712 cites W2165407899 @default.
- W4383720712 cites W2168076926 @default.
- W4383720712 cites W2265482648 @default.
- W4383720712 cites W2345018505 @default.
- W4383720712 cites W2437992816 @default.
- W4383720712 cites W2460215858 @default.
- W4383720712 cites W2559080278 @default.
- W4383720712 cites W2725719654 @default.
- W4383720712 cites W2770797413 @default.
- W4383720712 cites W2788457090 @default.
- W4383720712 cites W2807348649 @default.
- W4383720712 cites W4220990191 @default.
- W4383720712 cites W4295202617 @default.
- W4383720712 doi "https://doi.org/10.1210/jendso/bvad084" @default.
- W4383720712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37440964" @default.
- W4383720712 hasPublicationYear "2023" @default.
- W4383720712 type Work @default.
- W4383720712 citedByCount "0" @default.
- W4383720712 crossrefType "journal-article" @default.
- W4383720712 hasAuthorship W4383720712A5007551001 @default.
- W4383720712 hasAuthorship W4383720712A5020949961 @default.
- W4383720712 hasAuthorship W4383720712A5028070004 @default.
- W4383720712 hasAuthorship W4383720712A5030712568 @default.
- W4383720712 hasAuthorship W4383720712A5031834824 @default.
- W4383720712 hasAuthorship W4383720712A5031919664 @default.
- W4383720712 hasAuthorship W4383720712A5057692962 @default.
- W4383720712 hasAuthorship W4383720712A5062419704 @default.
- W4383720712 hasAuthorship W4383720712A5064525257 @default.
- W4383720712 hasAuthorship W4383720712A5069952259 @default.
- W4383720712 hasBestOaLocation W43837207121 @default.
- W4383720712 hasConcept C121332964 @default.
- W4383720712 hasConcept C121608353 @default.
- W4383720712 hasConcept C126322002 @default.
- W4383720712 hasConcept C142424586 @default.
- W4383720712 hasConcept C143998085 @default.
- W4383720712 hasConcept C159654299 @default.
- W4383720712 hasConcept C163764329 @default.
- W4383720712 hasConcept C203014093 @default.
- W4383720712 hasConcept C2776264508 @default.
- W4383720712 hasConcept C2778822529 @default.
- W4383720712 hasConcept C2778835679 @default.
- W4383720712 hasConcept C2779134260 @default.
- W4383720712 hasConcept C2779761222 @default.
- W4383720712 hasConcept C2779984678 @default.
- W4383720712 hasConcept C526584372 @default.
- W4383720712 hasConcept C71924100 @default.
- W4383720712 hasConcept C87355193 @default.
- W4383720712 hasConcept C90924648 @default.
- W4383720712 hasConceptScore W4383720712C121332964 @default.
- W4383720712 hasConceptScore W4383720712C121608353 @default.
- W4383720712 hasConceptScore W4383720712C126322002 @default.
- W4383720712 hasConceptScore W4383720712C142424586 @default.
- W4383720712 hasConceptScore W4383720712C143998085 @default.
- W4383720712 hasConceptScore W4383720712C159654299 @default.
- W4383720712 hasConceptScore W4383720712C163764329 @default.
- W4383720712 hasConceptScore W4383720712C203014093 @default.
- W4383720712 hasConceptScore W4383720712C2776264508 @default.
- W4383720712 hasConceptScore W4383720712C2778822529 @default.
- W4383720712 hasConceptScore W4383720712C2778835679 @default.
- W4383720712 hasConceptScore W4383720712C2779134260 @default.
- W4383720712 hasConceptScore W4383720712C2779761222 @default.
- W4383720712 hasConceptScore W4383720712C2779984678 @default.