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- W4383724172 endingPage "1091" @default.
- W4383724172 startingPage "1091" @default.
- W4383724172 abstract "One of the contributors to atherogenesis is enzymatically modified LDL (eLDL). eLDL was detected in all stages of aortic valve sclerosis and was demonstrated to trigger the activation of p38 mitogen-activated protein kinase (p38 MAPK), which has been identified as a pro-inflammatory protein in atherosclerosis. In this study, we investigated the influence of eLDL on IL-6 and IL-33 induction, and also the impact of eLDL on calcification in aortic valve stenosis (AS). eLDL upregulated phosphate-induced calcification in valvular interstitial cells (VICs)/myofibroblasts isolated from diseased aortic valves, as demonstrated by alizarin red staining. Functional studies demonstrated activation of p38 MAPK as well as an altered gene expression of osteogenic genes known to be involved in vascular calcification. In parallel with the activation of p38 MAPK, eLDL also induced upregulation of the cytokines IL-6 and IL-33. The results suggest a pro-calcifying role of eLDL in AS via induction of IL-6 and IL-33." @default.
- W4383724172 created "2023-07-11" @default.
- W4383724172 creator A5004914782 @default.
- W4383724172 creator A5030814855 @default.
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- W4383724172 creator A5057183308 @default.
- W4383724172 creator A5071315836 @default.
- W4383724172 creator A5092435344 @default.
- W4383724172 date "2023-07-07" @default.
- W4383724172 modified "2023-09-26" @default.
- W4383724172 title "Pro-Calcifying Role of Enzymatically Modified LDL (eLDL) in Aortic Valve Sclerosis via Induction of IL-6 and IL-33" @default.
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- W4383724172 doi "https://doi.org/10.3390/biom13071091" @default.
- W4383724172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37509127" @default.