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- W4383742200 abstract "Our objective was to evaluate whether pregnancy is prolonged by use of a proteomics-based maternal serum screening test followed by treatment interventions. This is a secondary analysis of the PREVENT-PTB randomized trial comparing screening with the PreTRM test versus no screening. The primary trial analysis found no significant between-group difference in preterm birth rate. Rather than considering a dichotomous outcome (preterm vs term), we treated gestational age at birth as a continuous variable using survival analysis. We also evaluated between-group difference in NICU length of stay and duration of respiratory support. Results indicated that pregnancy was significantly prolonged in subjects screened with PreTRM test compared to controls (adjusted hazard ratio 0.53, 95% confidence interval 0.36-0.78, P &lt;0.01). Newborns of screened subjects had significantly shorter NICU stay but no significant decrease in duration of respiratory support. In the PreTRM screen-positive group, interventions that were associated with pregnancy prolongation included care management and low-dose aspirin but not 17-hydroxyprogesterone caproate. We concluded that screening with the PreTRM test followed by interventions for screen-positive pregnancies can prolong pregnancy and reduce NICU-LOS." @default.
- W4383742200 created "2023-07-11" @default.
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- W4383742200 date "2023-07-10" @default.
- W4383742200 modified "2023-09-26" @default.
- W4383742200 title "Prediction and Prevention of Preterm Birth: Secondary Analysis of a Randomized Intervention Trial" @default.
- W4383742200 doi "https://doi.org/10.20944/preprints202307.0544.v1" @default.
- W4383742200 hasPublicationYear "2023" @default.
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