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- W4383744982 endingPage "188953" @default.
- W4383744982 startingPage "188953" @default.
- W4383744982 abstract "Protein phosphatase 2A (PP2A) inactivation is common in cancer, leading to sustained activation of pro-survival and growth-promoting pathways. PP2A consists of a scaffolding A-subunit, a catalytic C-subunit, and a regulatory B-subunit. The functional complexity of PP2A holoenzymes arises mainly through the vast repertoire of regulatory B-subunits, which determine both their substrate specificity and their subcellular localization. Therefore, a major challenge for developing more effective therapeutic strategies for cancer is to identify the specific PP2A complexes to be targeted. Of note, the development of small molecules specifically directed at PP2A-B56α has opened new therapeutic avenues in both solid and hematological tumors. Here, we focus on the B56/PR61 family of PP2A regulatory subunits, which have a central role in directing PP2A tumor suppressor activity. We provide an overview of the mechanisms controlling the formation and regulation of these complexes, the pathways they control, and the mechanisms underlying their deregulation in cancer." @default.
- W4383744982 created "2023-07-11" @default.
- W4383744982 creator A5022376380 @default.
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- W4383744982 creator A5065861193 @default.
- W4383744982 creator A5066125347 @default.
- W4383744982 creator A5082797212 @default.
- W4383744982 date "2023-09-01" @default.
- W4383744982 modified "2023-09-29" @default.
- W4383744982 title "Regulation and role of the PP2A-B56 holoenzyme family in cancer" @default.
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