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- W4383753623 abstract "Abstract Escherichia coli -associated native valve infective endocarditis is a rare disease that affects elderly patients with underlying risk factors such as diabetes mellitus, malignancy, and renal failure. Long-term use of calcium polystyrene sulfonate is a potential risk factor for gastrointestinal mucosal damage or even colorectal ulcers. Herein, we describe the fatal case of a 66-year-old Japanese man with diabetes mellitus and renal failure who had a calcium polystyrene sulfonate-induced rectal ulcer that led to E. coli native-valve infective endocarditis. The patient was admitted to our hospital with acute-onset impaired consciousness. As a result of the systemic investigation, he was diagnosed with E. coli bacteremia accompanied by multiple cerebral infarctions and an acute hemorrhagic rectal ulcer. Transesophageal echocardiography revealed a 20-mm vegetative structure on the mitral valve, resulting in a final diagnosis of E. coli -associated infective endocarditis. After rectal resection, mitral valve replacement surgery was performed; however, the patient died shortly after surgery. Pathological findings of the resected rectum showed deposition of a basophilic crystalline material suspected to be calcium polystyrene sulfonate. Our case highlights the potential risk of colorectal ulcers in patients with long-term use of calcium polystyrene sulfonate, triggering bacterial translocation and endocarditis as fatal complications." @default.
- W4383753623 created "2023-07-11" @default.
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- W4383753623 date "2023-07-10" @default.
- W4383753623 modified "2023-09-26" @default.
- W4383753623 title "Calcium polystyrene sulfonate-induced rectal ulcer causing E. coli native-valve infective endocarditis" @default.
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- W4383753623 doi "https://doi.org/10.21203/rs.3.rs-3090674/v1" @default.
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