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• W4383754265 abstract "Abstract The aim of this study was to clarify subclinical hidden interstitial lung disease (ILD) as a risk factor of severe pneumonia associated with coronavirus disease 2019 (COVID-19). We carefully examined autopsied lungs and chest computed tomography scanning (CT) images from patients with COVID-19 for interstitial lesions and then analyzed their relationship with disease severity. Among the autopsy series, subclinical ILD was found in 13/27 cases (48%) in the COVID-19 group, and in contrast, 8/65 (12%) in the control autopsy group ( p =0.0006; Fisher’s exact test). We reviewed CT images from the COVID-19 autopsy cases and verified that subclinical ILD was histologically detectable in the CT images. Then, we retrospectively examined CT images from another series of COVID-19 cases in the Yokohama, Japan area between February–August 2020 for interstitial lesions and analyzed the relationship to the severity of COVID-19 pneumonia. Interstitial lesion was more frequently found in the group with the moderate II/severe disease than in the moderate I/mild disease (severity was evaluated according to the COVID-19 severity classification system of the Ministry of Health, Labor, and Welfare [Japan]) (moderate II/severe, 11/15, 73.3% versus moderate I/mild, 108/245, 44.1%; Fisher exact test, p =0.0333). In conclusion, it was suggested that subclinical ILD could be an important risk factor for severe COVID-19 pneumonia. A benefit of these findings could be the development of a risk assessment system using high resolution CT images for fatal COVID-19 pneumonia." @default.
• W4383754265 created "2023-07-11" @default.
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• W4383754265 date "2023-07-10" @default.
• W4383754265 modified "2023-10-16" @default.
• W4383754265 title "Frequency of slight interstitial lung lesions in coronavirus disease 2019 autopsy cases - potential risk factor of severe pneumonia" @default.
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• W4383754265 doi "https://doi.org/10.21203/rs.3.rs-3122413/v1" @default.
• W4383754265 hasPublicationYear "2023" @default.
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