Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383814925> ?p ?o ?g. }
- W4383814925 abstract "Aging is accompanied by homeostatic and functional dysregulation of multiple immune cell subsets. Group 3 innate lymphoid cells (ILC3s) constitute a heterogeneous cell population that plays pivotal roles in intestinal immunity. In this study, we found that ILC3s in aged mice exhibited dysregulated homeostasis and function, leading to bacterial and fungal infection susceptibility. Moreover, our data revealed that the enrichment of the H3K4me3 modification in effector genes of aged gut CCR6+ ILC3s was specifically decreased compared to young mice counterparts. Disruption of Cxxc finger protein 1 (Cxxc1) activity, a key subunit of H3K4 methyltransferase, in ILC3s led to similar aging-related phenotypes. An integrated analysis revealed Kruppel-like factor 4 (Klf4) as a potential Cxxc1 target. Klf4 overexpression partially restored the differentiation and functional defects seen in both aged and Cxxc1-deficient intestinal CCR6+ ILC3s. Therefore, these data suggest that targeting intestinal ILC3s may provide strategies to protect against age-related infections. Shen, Gao and Luo et al. show that the epigenetic regulator Cxxc1 plays an important role in maintaining homeostasis and function of group 3 innate lymphoid cells that are involved and key in regulating intestinal immunity during aging." @default.
- W4383814925 created "2023-07-11" @default.
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- W4383814925 date "2023-07-10" @default.
- W4383814925 modified "2023-10-15" @default.
- W4383814925 title "Cxxc finger protein 1 maintains homeostasis and function of intestinal group 3 innate lymphoid cells with aging" @default.
- W4383814925 cites W1525207069 @default.
- W4383814925 cites W1579108180 @default.
- W4383814925 cites W1974104246 @default.
- W4383814925 cites W1976026025 @default.
- W4383814925 cites W1979408872 @default.
- W4383814925 cites W1981177186 @default.
- W4383814925 cites W1983930473 @default.
- W4383814925 cites W1990916340 @default.
- W4383814925 cites W1998440908 @default.
- W4383814925 cites W2000088222 @default.
- W4383814925 cites W2010291571 @default.
- W4383814925 cites W2023752776 @default.
- W4383814925 cites W2024183493 @default.
- W4383814925 cites W2027768860 @default.
- W4383814925 cites W2036265947 @default.
- W4383814925 cites W2040890014 @default.
- W4383814925 cites W2048408764 @default.
- W4383814925 cites W2067320696 @default.
- W4383814925 cites W2067850515 @default.
- W4383814925 cites W2075545024 @default.
- W4383814925 cites W2078003979 @default.
- W4383814925 cites W2088861927 @default.
- W4383814925 cites W2091674262 @default.
- W4383814925 cites W2092138220 @default.
- W4383814925 cites W2095753163 @default.
- W4383814925 cites W2106462080 @default.
- W4383814925 cites W2112627805 @default.
- W4383814925 cites W2113474671 @default.
- W4383814925 cites W2121910267 @default.
- W4383814925 cites W2126525177 @default.
- W4383814925 cites W2149789162 @default.
- W4383814925 cites W2152414109 @default.
- W4383814925 cites W2170551349 @default.
- W4383814925 cites W2179438025 @default.
- W4383814925 cites W2287943396 @default.
- W4383814925 cites W2336716120 @default.
- W4383814925 cites W2345615811 @default.
- W4383814925 cites W2346743834 @default.
- W4383814925 cites W2397203673 @default.
- W4383814925 cites W2431543454 @default.
- W4383814925 cites W2471110308 @default.
- W4383814925 cites W2513741268 @default.
- W4383814925 cites W2517275410 @default.
- W4383814925 cites W2528480688 @default.
- W4383814925 cites W2560624107 @default.
- W4383814925 cites W2594849481 @default.
- W4383814925 cites W2601730880 @default.
- W4383814925 cites W2677397198 @default.
- W4383814925 cites W2769255069 @default.
- W4383814925 cites W2775503072 @default.
- W4383814925 cites W2793031138 @default.
- W4383814925 cites W2797192791 @default.
- W4383814925 cites W2797583006 @default.
- W4383814925 cites W2800392236 @default.
- W4383814925 cites W2885476822 @default.
- W4383814925 cites W2888376450 @default.
- W4383814925 cites W2889631761 @default.
- W4383814925 cites W2920191405 @default.
- W4383814925 cites W2942760976 @default.
- W4383814925 cites W2954254686 @default.
- W4383814925 cites W2979906277 @default.
- W4383814925 cites W2984472267 @default.
- W4383814925 cites W2986345758 @default.
- W4383814925 cites W2993500691 @default.
- W4383814925 cites W3000690579 @default.
- W4383814925 cites W3005016654 @default.
- W4383814925 cites W3005331653 @default.
- W4383814925 cites W3009666649 @default.
- W4383814925 cites W3015314979 @default.
- W4383814925 cites W3041996543 @default.
- W4383814925 cites W3106188259 @default.
- W4383814925 cites W3110523587 @default.
- W4383814925 cites W3131384840 @default.
- W4383814925 cites W3160268512 @default.
- W4383814925 cites W3163546726 @default.
- W4383814925 cites W3165970915 @default.
- W4383814925 cites W3183154475 @default.
- W4383814925 cites W3185614498 @default.
- W4383814925 cites W3200345171 @default.
- W4383814925 cites W3202649987 @default.