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- W4383822692 abstract "Abstract Opioid use disorders (OUD) and opioid-related fatal overdoses are a public health concern in the United States. Approximately 100,000 fatal opioid-related overdoses occurred annually from mid-2020 to the present, the majority of which involved fentanyl or fentanyl analogs. Vaccines have been proposed as a therapeutic and prophylactic strategy to offer selective and long-lasting protection against accidental or deliberate exposure to fentanyl and closely related analogs. To support the development of a clinically viable anti-opioid vaccine suitable for human use, the incorporation of adjuvants will be required to elicit high titers of high-affinity circulating antibodies specific to the target opioid. Here we demonstrate that the addition of a synthetic TLR7/8 agonist, INI-4001, but not a synthetic TLR4 agonist, INI-2002, to a candidate conjugate vaccine consisting of a fentanyl-based hapten, F 1 , conjugated to the diphtheria cross-reactive material (CRM), significantly increased generation of high-affinity F 1 -specific antibody concentrations, and reduced drug distribution to the brain after fentanyl administration in mice." @default.
- W4383822692 created "2023-07-11" @default.
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- W4383822692 date "2023-07-10" @default.
- W4383822692 modified "2023-10-17" @default.
- W4383822692 title "A lipidated TLR7/8 adjuvant enhances the efficacy of a vaccine against fentanyl in mice" @default.
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- W4383822692 doi "https://doi.org/10.1038/s41541-023-00694-y" @default.
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