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- W4383872774 abstract "Recognition of pathogen-associated molecular patterns can trigger the IRE1α arm of the endoplasmic reticulum (ER) stress response in innate immune cells. This process maintains ER homeostasis and also coordinates diverse immunomodulatory programs during bacterial and viral infections. However, the role of innate IRE1α signaling in response to fungal pathogens remains elusive. Here, we report that systemic infection with the human opportunistic fungal pathogen Candida albicans induces proinflammatory IRE1α hyperactivation in myeloid cells that leads to fatal kidney immunopathology. Mechanistically, simultaneous activation of the TLR/IL-1R adaptor protein MyD88 and the C-type lectin receptor Dectin-1 by C. albicans induced NADPH oxidase-driven generation of reactive oxygen species that caused ER stress and IRE1α-dependent overexpression of key inflammatory mediators such as IL-1β, IL-6, CCL5, PGE2 and TNFα. Selective ablation of IRE1α in leukocytes, or treatment with an IRE1α pharmacological inhibitor, mitigated kidney inflammation and prolonged the survival of mice with systemic C. albicans infection. Therefore, controlling IRE1α hyperactivation may be useful for impeding the immunopathogenic progression of disseminated candidiasis." @default.
- W4383872774 created "2023-07-12" @default.
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- W4383872774 date "2023-09-01" @default.
- W4383872774 modified "2023-09-27" @default.
- W4383872774 title "Inflammatory ER stress responses dictate the immunopathogenic progression of systemic candidiasis" @default.
- W4383872774 cites W1529247370 @default.
- W4383872774 cites W1561349380 @default.
- W4383872774 cites W1627009127 @default.
- W4383872774 cites W1881900824 @default.
- W4383872774 cites W1955652166 @default.
- W4383872774 cites W1976925504 @default.
- W4383872774 cites W1978719672 @default.
- W4383872774 cites W1983031293 @default.
- W4383872774 cites W1986158733 @default.
- W4383872774 cites W1987998552 @default.
- W4383872774 cites W1989955016 @default.
- W4383872774 cites W1993688639 @default.
- W4383872774 cites W1997619660 @default.
- W4383872774 cites W1997684038 @default.
- W4383872774 cites W2002817805 @default.
- W4383872774 cites W2007390167 @default.
- W4383872774 cites W2007921798 @default.
- W4383872774 cites W2008415419 @default.
- W4383872774 cites W2010457001 @default.
- W4383872774 cites W2023538413 @default.
- W4383872774 cites W2025355874 @default.
- W4383872774 cites W2025846979 @default.
- W4383872774 cites W2031701891 @default.
- W4383872774 cites W2043092806 @default.
- W4383872774 cites W2045197807 @default.
- W4383872774 cites W2050069950 @default.
- W4383872774 cites W2052203880 @default.
- W4383872774 cites W2060721894 @default.
- W4383872774 cites W2064045962 @default.
- W4383872774 cites W2066222426 @default.
- W4383872774 cites W2068133291 @default.
- W4383872774 cites W2073067684 @default.
- W4383872774 cites W2079944569 @default.
- W4383872774 cites W2085921490 @default.
- W4383872774 cites W2088978171 @default.
- W4383872774 cites W2090895449 @default.
- W4383872774 cites W2095471892 @default.
- W4383872774 cites W2095726706 @default.
- W4383872774 cites W2106519526 @default.
- W4383872774 cites W2107794472 @default.
- W4383872774 cites W2109747408 @default.
- W4383872774 cites W2111697888 @default.
- W4383872774 cites W2113143691 @default.
- W4383872774 cites W2122345674 @default.
- W4383872774 cites W2124325113 @default.
- W4383872774 cites W2126924404 @default.
- W4383872774 cites W2127906377 @default.
- W4383872774 cites W2130410032 @default.
- W4383872774 cites W2131750038 @default.
- W4383872774 cites W2137019479 @default.
- W4383872774 cites W2144035662 @default.
- W4383872774 cites W2146057612 @default.
- W4383872774 cites W2152899800 @default.
- W4383872774 cites W2158373279 @default.
- W4383872774 cites W2161821256 @default.
- W4383872774 cites W2169011380 @default.
- W4383872774 cites W2176721723 @default.
- W4383872774 cites W2179438025 @default.
- W4383872774 cites W2192080449 @default.
- W4383872774 cites W2214074259 @default.
- W4383872774 cites W2231006224 @default.
- W4383872774 cites W2234993746 @default.
- W4383872774 cites W2323326409 @default.
- W4383872774 cites W2483585301 @default.
- W4383872774 cites W2500842273 @default.
- W4383872774 cites W2506705299 @default.
- W4383872774 cites W2580946396 @default.
- W4383872774 cites W2703960277 @default.
- W4383872774 cites W2747004888 @default.
- W4383872774 cites W2788525877 @default.
- W4383872774 cites W2790537916 @default.
- W4383872774 cites W2794422589 @default.
- W4383872774 cites W2802737225 @default.
- W4383872774 cites W2809161821 @default.
- W4383872774 cites W2886095503 @default.
- W4383872774 cites W2913738584 @default.