Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383872873> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4383872873 abstract "A novel buprenorphine (BUP) extended-release formulation (BUP-XR) produced as a lipid-encapsulated, low viscosity BUP suspension for subcutaneous (SC) injection to control pain was evaluated for pharmacokinetics and safety in four adult male cynomolgus monkeys.Each animal was given 0.2 mg/kg reformulated BUP-XR SC. Clinical observations were made during the course of the study. Blood samples were obtained from each animal before BUP-XR administration, 6, 24, 48, 72, and 96 h post-BUP-XR injection. Plasma levels of buprenorphine were analyzed using HPLC-MS/MS. The PK values calculated included peak plasma concentration of the BUP analyte, time to peak plasma concentration, plasma half-life, area under the plasma concentration-time curve, clearance, apparent volume of distribution, and elimination rate constant (Cmax , Tmax , T½ , AUC0-t , CL, Vd, and Ke, respectively).Observable adverse clinical signs were not detected. BUP concentration peaked from 6 to 48 h, then declined in a linear fashion. Quantifiable plasma BUP was measured in all monkeys at all time points. Results indicate that a single BUP-XR dose at 0.2 mg/kg can reliably provide plasma levels of BUP reported in the literature to be therapeutically relevant for up to 96 h.Because of the lack of any clinical observations or adverse effects at the injection site or absence of observable abnormal behaviors, it may be concluded that the use of BUP-XR is safe and efficacious in this species of non-human primate at the dose regimen described in this study for up to 96 h post-administration." @default.
- W4383872873 created "2023-07-12" @default.
- W4383872873 creator A5019921106 @default.
- W4383872873 creator A5037006790 @default.
- W4383872873 creator A5047195747 @default.
- W4383872873 creator A5054140893 @default.
- W4383872873 date "2023-07-11" @default.
- W4383872873 modified "2023-09-25" @default.
- W4383872873 title "A pharmacokinetic study of extended‐release buprenorphine in cynomolgus monkeys (Macaca fasicularis)" @default.
- W4383872873 cites W2074434025 @default.
- W4383872873 cites W2885120637 @default.
- W4383872873 cites W2952108540 @default.
- W4383872873 cites W2996019109 @default.
- W4383872873 cites W2997743530 @default.
- W4383872873 cites W3114219779 @default.
- W4383872873 cites W3132647833 @default.
- W4383872873 cites W3175939848 @default.
- W4383872873 cites W3196266104 @default.
- W4383872873 cites W4385146542 @default.
- W4383872873 doi "https://doi.org/10.1111/jmp.12661" @default.
- W4383872873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37432036" @default.
- W4383872873 hasPublicationYear "2023" @default.
- W4383872873 type Work @default.
- W4383872873 citedByCount "0" @default.
- W4383872873 crossrefType "journal-article" @default.
- W4383872873 hasAuthorship W4383872873A5019921106 @default.
- W4383872873 hasAuthorship W4383872873A5037006790 @default.
- W4383872873 hasAuthorship W4383872873A5047195747 @default.
- W4383872873 hasAuthorship W4383872873A5054140893 @default.
- W4383872873 hasBestOaLocation W43838728731 @default.
- W4383872873 hasConcept C112705442 @default.
- W4383872873 hasConcept C139254425 @default.
- W4383872873 hasConcept C140793950 @default.
- W4383872873 hasConcept C170493617 @default.
- W4383872873 hasConcept C179998833 @default.
- W4383872873 hasConcept C185592680 @default.
- W4383872873 hasConcept C22979827 @default.
- W4383872873 hasConcept C2777389121 @default.
- W4383872873 hasConcept C2778949969 @default.
- W4383872873 hasConcept C2781063702 @default.
- W4383872873 hasConcept C3020079912 @default.
- W4383872873 hasConcept C42219234 @default.
- W4383872873 hasConcept C43617362 @default.
- W4383872873 hasConcept C55493867 @default.
- W4383872873 hasConcept C71924100 @default.
- W4383872873 hasConcept C86803240 @default.
- W4383872873 hasConcept C98274493 @default.
- W4383872873 hasConceptScore W4383872873C112705442 @default.
- W4383872873 hasConceptScore W4383872873C139254425 @default.
- W4383872873 hasConceptScore W4383872873C140793950 @default.
- W4383872873 hasConceptScore W4383872873C170493617 @default.
- W4383872873 hasConceptScore W4383872873C179998833 @default.
- W4383872873 hasConceptScore W4383872873C185592680 @default.
- W4383872873 hasConceptScore W4383872873C22979827 @default.
- W4383872873 hasConceptScore W4383872873C2777389121 @default.
- W4383872873 hasConceptScore W4383872873C2778949969 @default.
- W4383872873 hasConceptScore W4383872873C2781063702 @default.
- W4383872873 hasConceptScore W4383872873C3020079912 @default.
- W4383872873 hasConceptScore W4383872873C42219234 @default.
- W4383872873 hasConceptScore W4383872873C43617362 @default.
- W4383872873 hasConceptScore W4383872873C55493867 @default.
- W4383872873 hasConceptScore W4383872873C71924100 @default.
- W4383872873 hasConceptScore W4383872873C86803240 @default.
- W4383872873 hasConceptScore W4383872873C98274493 @default.
- W4383872873 hasLocation W43838728731 @default.
- W4383872873 hasLocation W43838728732 @default.
- W4383872873 hasOpenAccess W4383872873 @default.
- W4383872873 hasPrimaryLocation W43838728731 @default.
- W4383872873 hasRelatedWork W2083640028 @default.
- W4383872873 hasRelatedWork W2109865776 @default.
- W4383872873 hasRelatedWork W2125585793 @default.
- W4383872873 hasRelatedWork W2351251703 @default.
- W4383872873 hasRelatedWork W2576834138 @default.
- W4383872873 hasRelatedWork W2605594768 @default.
- W4383872873 hasRelatedWork W2996420923 @default.
- W4383872873 hasRelatedWork W3003535682 @default.
- W4383872873 hasRelatedWork W3024645604 @default.
- W4383872873 hasRelatedWork W4246971521 @default.
- W4383872873 isParatext "false" @default.
- W4383872873 isRetracted "false" @default.
- W4383872873 workType "article" @default.