FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383873281> ?p ?o ?g. }

• W4383873281 endingPage "7" @default.
• W4383873281 startingPage "1" @default.
• W4383873281 abstract "Fetal restriction (FR) alters insulin sensitivity, but it is unknown how the metabolic profile associated with restriction affects development of the dopamine (DA) system and DA-related behaviors. The Netrin-1/DCC guidance cue system participates in maturation of the mesocorticolimbic DA circuitry. Therefore, our objective was to identify if FR modifies Netrin-1/DCC receptor protein expression in the prefrontal cortex (PFC) at birth and mRNA in adulthood in rodent males. We used cultured HEK293 cells to assess if levels of miR-218, microRNA regulator of DCC, are sensitive to insulin. To assess this, pregnant dams were subjected to a 50% FR diet from gestational day 10 until birth. Medial PFC (mPFC) DCC/Netrin-1 protein expression was measured at P0 at baseline and Dcc/Netrin-1 mRNA levels were quantified in adults 15 min after a saline/insulin injection. miR-218 levels in HEK-293 cells were measured in response to insulin exposure. At P0, Netrin-1 levels are downregulated in FR animals in comparison to controls. In adult rodents, insulin administration results in an increase in Dcc mRNA levels in control but not FR rats. In HEK293 cells, there is a positive correlation between insulin concentration and miR-218 levels. Since miR-218 is a Dcc gene expression regulator and our in vitro results show that insulin regulates miR-218 levels, we suggest that FR-induced changes in insulin sensitivity could be affecting Dcc expression via miR-218, impacting DA system maturation and organization. As fetal adversity is linked to nonadaptive behaviors later in life, this may contribute to early identification of vulnerability to chronic diseases associated with fetal adversity." @default.
• W4383873281 created "2023-07-12" @default.
• W4383873281 creator A5003260679 @default.
• W4383873281 creator A5006567925 @default.
• W4383873281 creator A5012704186 @default.
• W4383873281 creator A5026230092 @default.
• W4383873281 creator A5030477051 @default.
• W4383873281 creator A5031496211 @default.
• W4383873281 creator A5041185884 @default.
• W4383873281 creator A5052636359 @default.
• W4383873281 creator A5057559412 @default.
• W4383873281 creator A5057757844 @default.
• W4383873281 creator A5073559616 @default.
• W4383873281 creator A5088745102 @default.
• W4383873281 date "2023-07-11" @default.
• W4383873281 modified "2023-10-11" @default.
• W4383873281 title "Relationship between insulin and Netrin-1/DCC guidance cue pathway regulation in the prefrontal cortex of rodents exposed to prenatal dietary restriction" @default.
• W4383873281 cites W1533010316 @default.
• W4383873281 cites W1682292166 @default.
• W4383873281 cites W1762453280 @default.
• W4383873281 cites W1934095277 @default.
• W4383873281 cites W1964743988 @default.
• W4383873281 cites W1964798322 @default.
• W4383873281 cites W1967567809 @default.
• W4383873281 cites W1974123684 @default.
• W4383873281 cites W1974218049 @default.
• W4383873281 cites W1980298089 @default.
• W4383873281 cites W1980535438 @default.
• W4383873281 cites W1982691704 @default.
• W4383873281 cites W1982830599 @default.
• W4383873281 cites W1982959891 @default.
• W4383873281 cites W1995667490 @default.
• W4383873281 cites W1995734197 @default.
• W4383873281 cites W2006599836 @default.
• W4383873281 cites W2007154912 @default.
• W4383873281 cites W2011484135 @default.
• W4383873281 cites W2015838103 @default.
• W4383873281 cites W2025189383 @default.
• W4383873281 cites W2030576952 @default.
• W4383873281 cites W2033160222 @default.
• W4383873281 cites W2037980186 @default.
• W4383873281 cites W2039966754 @default.
• W4383873281 cites W2048981264 @default.
• W4383873281 cites W2052935503 @default.
• W4383873281 cites W2054999647 @default.
• W4383873281 cites W2067476005 @default.
• W4383873281 cites W2070524897 @default.
• W4383873281 cites W2072337863 @default.
• W4383873281 cites W2082125488 @default.
• W4383873281 cites W2089001345 @default.
• W4383873281 cites W2089312971 @default.
• W4383873281 cites W2090212852 @default.
• W4383873281 cites W2097155839 @default.
• W4383873281 cites W2098227792 @default.
• W4383873281 cites W2101671662 @default.
• W4383873281 cites W2110952210 @default.
• W4383873281 cites W2116608031 @default.
• W4383873281 cites W2121691462 @default.
• W4383873281 cites W2126108743 @default.
• W4383873281 cites W2127501908 @default.
• W4383873281 cites W2127619757 @default.
• W4383873281 cites W2129232673 @default.
• W4383873281 cites W2144902188 @default.
• W4383873281 cites W2158068037 @default.
• W4383873281 cites W2170326236 @default.
• W4383873281 cites W2302100165 @default.
• W4383873281 cites W2327202400 @default.
• W4383873281 cites W2403422514 @default.
• W4383873281 cites W2418748266 @default.
• W4383873281 cites W2514630415 @default.
• W4383873281 cites W2761155091 @default.
• W4383873281 cites W2770107920 @default.
• W4383873281 cites W2804410858 @default.
• W4383873281 cites W2890468812 @default.
• W4383873281 cites W2907422710 @default.
• W4383873281 cites W2915738226 @default.
• W4383873281 cites W2921421048 @default.
• W4383873281 cites W2981964842 @default.
• W4383873281 cites W3003308468 @default.
• W4383873281 cites W3021375251 @default.
• W4383873281 cites W3023003145 @default.
• W4383873281 cites W3037733366 @default.
• W4383873281 cites W3097067095 @default.
• W4383873281 cites W3155442780 @default.
• W4383873281 cites W3214635771 @default.
• W4383873281 cites W337276882 @default.
• W4383873281 cites W4288080690 @default.
• W4383873281 cites W4298228560 @default.
• W4383873281 cites W757322814 @default.
• W4383873281 doi "https://doi.org/10.1017/s204017442300017x" @default.
• W4383873281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37431265" @default.
• W4383873281 hasPublicationYear "2023" @default.
• W4383873281 type Work @default.
• W4383873281 citedByCount "0" @default.
• W4383873281 crossrefType "journal-article" @default.
• W4383873281 hasAuthorship W4383873281A5003260679 @default.
• W4383873281 hasAuthorship W4383873281A5006567925 @default.
• W4383873281 hasAuthorship W4383873281A5012704186 @default.

• next