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• W4383874370 abstract "Abstract Clinical avian coccidiosis is typically caused by co-infection with several Eimeria species. Recombinant protein and DNA vaccines have shown promising prospects in controlling coccidiosis. On this basis, DNA vaccines that encode multiple epitopes from different Eimeria species may provide broad protection against co-infections. In this study, we designed a fusion gene fragment, 14EGT, that contained concentrated T-cell epitopes from four common antigens of Eimeria species (14-3-3, elongation factor 2, glyceraldehyde-3-phosphate dehydrogenase, and transhydrogenase). Multi-epitope DNA vaccine pVAX1-14EGT and recombinant protein vaccine pET-32a-14EGT (r14EGT) were then created based on the 14EGT fragment. Subsequently, cellular and humoral immune responses were measured in vaccinated chickens. Vaccination-challenge trials were also conducted, where the birds were vaccinated with the 14EGT preparations and later exposed to single or multiple Eimeria species to evaluate the protective efficacy of the vaccines. According to the results, vaccination with 14EGT preparations effectively upregulated the proportions of CD4 + and CD8 + T cells and the levels of Th1 and Th2 hallmark cytokines. The levels of serum IgG antibodies were also significantly increased. Animal vaccination trials revealed the alleviated enteric lesions, weight loss, and oocysts output compared to the control groups. The preparations were found to be moderately effective against single Eimeria species, with the anticoccidial index (ACI) ranging from 160 to 180. However, when challenged with multiple Eimeria species, the protection provided by the 14EGT preparations was not satisfactory, with ACI of 142.18 and 146.41, respectively. Collectively, the results suggest that a multi-epitope vaccine that encodes the T-cell epitopes of common antigens derived from Eimeria parasites could be a potential and effective strategy to control avian coccidiosis." @default.
• W4383874370 created "2023-07-12" @default.
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• W4383874370 date "2023-07-11" @default.
• W4383874370 modified "2023-09-23" @default.
• W4383874370 title "Protective efficacies of multi-epitope DNA subunit vaccine constructed from common antigens of Eimeria species in chickens" @default.
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• W4383874370 doi "https://doi.org/10.21203/rs.3.rs-3135850/v1" @default.
• W4383874370 hasPublicationYear "2023" @default.
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