Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383875493> ?p ?o ?g. }
- W4383875493 abstract "The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants and anatomical escape characteristics threaten the effectiveness of current coronavirus disease 2019 (COVID-19) vaccines. There is an urgent need to understand the immunological mechanism of broad-spectrum respiratory tract protection to guide broader vaccines development. Here we investigate immune responses induced by an NS1-deleted influenza virus vectored intranasal COVID-19 vaccine (dNS1-RBD) which provides broad-spectrum protection against SARS-CoV-2 variants in hamsters. Intranasal delivery of dNS1-RBD induces innate immunity, trained immunity and tissue-resident memory T cells covering the upper and lower respiratory tract. It restrains the inflammatory response by suppressing early phase viral load post SARS-CoV-2 challenge and attenuating pro-inflammatory cytokine (Il6, Il1b, and Ifng) levels, thereby reducing excess immune-induced tissue injury compared with the control group. By inducing local cellular immunity and trained immunity, intranasal delivery of NS1-deleted influenza virus vectored vaccine represents a broad-spectrum COVID-19 vaccine strategy to reduce disease burden." @default.
- W4383875493 created "2023-07-12" @default.
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- W4383875493 date "2023-07-11" @default.
- W4383875493 modified "2023-09-30" @default.
- W4383875493 title "Intranasal influenza-vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response in hamsters" @default.
- W4383875493 cites W1859780204 @default.
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- W4383875493 cites W1973433801 @default.
- W4383875493 cites W1988511365 @default.
- W4383875493 cites W2020744745 @default.
- W4383875493 cites W2027768860 @default.
- W4383875493 cites W2029903525 @default.
- W4383875493 cites W2038689279 @default.
- W4383875493 cites W2051890542 @default.
- W4383875493 cites W2084141237 @default.
- W4383875493 cites W2089573422 @default.
- W4383875493 cites W2111693224 @default.
- W4383875493 cites W2115707764 @default.
- W4383875493 cites W2124392720 @default.
- W4383875493 cites W2141171505 @default.
- W4383875493 cites W2155051381 @default.
- W4383875493 cites W2336656712 @default.
- W4383875493 cites W2473001391 @default.
- W4383875493 cites W2543995928 @default.
- W4383875493 cites W2610618910 @default.
- W4383875493 cites W2620974035 @default.
- W4383875493 cites W2765851264 @default.
- W4383875493 cites W2893763073 @default.
- W4383875493 cites W2898375074 @default.
- W4383875493 cites W2902723093 @default.
- W4383875493 cites W2911366108 @default.
- W4383875493 cites W2913912691 @default.
- W4383875493 cites W2928871599 @default.
- W4383875493 cites W2936985008 @default.
- W4383875493 cites W2945777288 @default.
- W4383875493 cites W2967035454 @default.
- W4383875493 cites W2974248066 @default.
- W4383875493 cites W3004280078 @default.
- W4383875493 cites W3009091764 @default.
- W4383875493 cites W3011483298 @default.
- W4383875493 cites W3014233146 @default.
- W4383875493 cites W3016489853 @default.
- W4383875493 cites W3018079554 @default.
- W4383875493 cites W3021560285 @default.
- W4383875493 cites W3022878099 @default.
- W4383875493 cites W3025871232 @default.
- W4383875493 cites W3038974679 @default.
- W4383875493 cites W3042183476 @default.
- W4383875493 cites W3049654234 @default.
- W4383875493 cites W3083820245 @default.
- W4383875493 cites W3084118349 @default.
- W4383875493 cites W3094541679 @default.
- W4383875493 cites W3123967880 @default.
- W4383875493 cites W3139922556 @default.
- W4383875493 cites W3144105768 @default.
- W4383875493 cites W3160121817 @default.
- W4383875493 cites W3165479483 @default.
- W4383875493 cites W3182774911 @default.