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- W4383888891 abstract " The pathogenic correlation of mast cells (MCs) with HPV infection in oral squamous cell carcinoma (OSCC) is still a subject of controversy. In this study we aimed to compare the mast cell density (MCD) between healthy gingival and OSCC samples, evaluate the association of MCD with the clinicopathological data, correlate the MCD with stromal tumor infiltration lymphocytes (sTIL) and HPV status of OSCC specimens. This study was carried out on 86 specimens of HPV positive and negative OSCC and 20 samples of healthy gingiva, MCD was evaluated using toluidine blue stain. The MCD in healthy gingival and OSCC specimens was 1.76 ± 0.696 and 10.25 ± 2.227 respectively, with P value of < 0.001. In OSCC, MCD was significantly correlated with histological grade of the tumor, no significant correlations were observed between MCD with HPV (r= 0.064, p= 0.556) and sTIL (r= 0.084, p= 0.439), while, fair significant correlations were found between HPV and sTIL (r = 0.285, p= 0.007). We concluded that MCs have a pro tumorigenic effects, however, MCs did not appear to have a role in HPV related OSCC in reverse to sTIL which showed a significant correlation with HPV carcinogenesis" @default.
- W4383888891 created "2023-07-12" @default.
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- W4383888891 date "2023-04-25" @default.
- W4383888891 modified "2023-10-16" @default.
- W4383888891 title "Interplay of Mast Cells, Hpv, And Tumor Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma" @default.
- W4383888891 doi "https://doi.org/10.26682/sjuod.2023.26.1.41" @default.
- W4383888891 hasPublicationYear "2023" @default.
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