FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383894977> ?p ?o ?g. }

• W4383894977 abstract "Cellular senescence may be associated with morphological changes in skeletal muscle and changes in physical function with age although there have been few human studies. We aimed to determine the feasibility of characterising cellular senescence in skeletal muscle and explored sex-specific associations between markers of cellular senescence, muscle morphology, and physical function in participants from the MASS_Lifecourse Study. Senescence markers (p16, TAF (Telomere-Associated DNA Damage Foci), HMGB1 (High Mobility Group Box 1), and Lamin B1) and morphological characteristics (fibre size, number, fibrosis, and centrally nucleated fibres) were assessed in muscle biopsies from 40 men and women (age range 47-84) using spatially-resolved methods (immunohistochemistry, immunofluorescence, and RNA and fluorescence in situ hybridisation). The associations between senescence, morphology, and physical function (muscle strength, mass, and physical performance) at different ages were explored. We found that most senescence markers and morphological characteristics were weakly associated with age in men but more strongly, although non-significantly, associated with age in women. Associations between senescence markers, morphology, and physical function were also stronger in women for HMGB1 and grip strength (r = 0.52); TAF, BMI, and muscle mass (r > 0.4); Lamin B1 and fibrosis (r = - 0.5); fibre size and muscle mass (r ≥ 0.4); and gait speed (r = - 0.5). However, these associations were non-significant. In conclusion, we have demonstrated that it is feasible to characterise cellular senescence in human skeletal muscle and to explore associations with morphology and physical function in women and men of different ages. The findings require replication in larger studies." @default.
• W4383894977 created "2023-07-12" @default.
• W4383894977 creator A5003206975 @default.
• W4383894977 creator A5010019802 @default.
• W4383894977 creator A5010418551 @default.
• W4383894977 creator A5043576814 @default.
• W4383894977 creator A5057916244 @default.
• W4383894977 creator A5084179238 @default.
• W4383894977 creator A5088063654 @default.
• W4383894977 creator A5088614184 @default.
• W4383894977 date "2023-07-11" @default.
• W4383894977 modified "2023-10-14" @default.
• W4383894977 title "Determining the feasibility of characterising cellular senescence in human skeletal muscle and exploring associations with muscle morphology and physical function at different ages: findings from the MASS_Lifecourse Study" @default.
• W4383894977 cites W1524549603 @default.
• W4383894977 cites W1870980090 @default.
• W4383894977 cites W1982925468 @default.
• W4383894977 cites W1990435249 @default.
• W4383894977 cites W1992384426 @default.
• W4383894977 cites W1994917595 @default.
• W4383894977 cites W2005989770 @default.
• W4383894977 cites W2017311214 @default.
• W4383894977 cites W2028169108 @default.
• W4383894977 cites W2069519394 @default.
• W4383894977 cites W2119150168 @default.
• W4383894977 cites W2124405724 @default.
• W4383894977 cites W2130458932 @default.
• W4383894977 cites W2140930678 @default.
• W4383894977 cites W2155173050 @default.
• W4383894977 cites W2159294672 @default.
• W4383894977 cites W2165869751 @default.
• W4383894977 cites W2167279371 @default.
• W4383894977 cites W2168898965 @default.
• W4383894977 cites W2262352538 @default.
• W4383894977 cites W2516372925 @default.
• W4383894977 cites W2739438570 @default.
• W4383894977 cites W2757550654 @default.
• W4383894977 cites W2762920249 @default.
• W4383894977 cites W2767602808 @default.
• W4383894977 cites W2788548733 @default.
• W4383894977 cites W2797582634 @default.
• W4383894977 cites W2860743873 @default.
• W4383894977 cites W2884048133 @default.
• W4383894977 cites W2894049215 @default.
• W4383894977 cites W2897513125 @default.
• W4383894977 cites W2906721882 @default.
• W4383894977 cites W2912918280 @default.
• W4383894977 cites W2946262636 @default.
• W4383894977 cites W2988310131 @default.
• W4383894977 cites W2999612022 @default.
• W4383894977 cites W3014314962 @default.
• W4383894977 cites W3027385411 @default.
• W4383894977 cites W3042236956 @default.
• W4383894977 cites W3080491980 @default.
• W4383894977 cites W3099661466 @default.
• W4383894977 cites W3107203586 @default.
• W4383894977 cites W3126225491 @default.
• W4383894977 cites W3147103840 @default.
• W4383894977 cites W4205268013 @default.
• W4383894977 cites W4205930540 @default.
• W4383894977 cites W4211037299 @default.
• W4383894977 cites W4211144975 @default.
• W4383894977 cites W4249247529 @default.
• W4383894977 cites W4283758110 @default.
• W4383894977 cites W4285490572 @default.
• W4383894977 cites W4292004337 @default.
• W4383894977 cites W4307112113 @default.
• W4383894977 cites W4308767256 @default.
• W4383894977 cites W4313419476 @default.
• W4383894977 doi "https://doi.org/10.1007/s11357-023-00869-4" @default.
• W4383894977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37434081" @default.
• W4383894977 hasPublicationYear "2023" @default.
• W4383894977 type Work @default.
• W4383894977 citedByCount "0" @default.
• W4383894977 crossrefType "journal-article" @default.
• W4383894977 hasAuthorship W4383894977A5003206975 @default.
• W4383894977 hasAuthorship W4383894977A5010019802 @default.
• W4383894977 hasAuthorship W4383894977A5010418551 @default.
• W4383894977 hasAuthorship W4383894977A5043576814 @default.
• W4383894977 hasAuthorship W4383894977A5057916244 @default.
• W4383894977 hasAuthorship W4383894977A5084179238 @default.
• W4383894977 hasAuthorship W4383894977A5088063654 @default.
• W4383894977 hasAuthorship W4383894977A5088614184 @default.
• W4383894977 hasBestOaLocation W43838949771 @default.
• W4383894977 hasConcept C104317684 @default.
• W4383894977 hasConcept C126322002 @default.
• W4383894977 hasConcept C134018914 @default.
• W4383894977 hasConcept C177336024 @default.
• W4383894977 hasConcept C179093185 @default.
• W4383894977 hasConcept C2776214593 @default.
• W4383894977 hasConcept C2779959927 @default.
• W4383894977 hasConcept C522857546 @default.
• W4383894977 hasConcept C54355233 @default.
• W4383894977 hasConcept C71924100 @default.
• W4383894977 hasConcept C86803240 @default.
• W4383894977 hasConcept C95444343 @default.
• W4383894977 hasConceptScore W4383894977C104317684 @default.
• W4383894977 hasConceptScore W4383894977C126322002 @default.
• W4383894977 hasConceptScore W4383894977C134018914 @default.
• W4383894977 hasConceptScore W4383894977C177336024 @default.
• W4383894977 hasConceptScore W4383894977C179093185 @default.

• next