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- W4383894987 abstract "Antimicrobial resistance has emerged as a global public health threat, and development of novel therapeutics for treating infections caused by multi-drug resistant bacteria is urgent. Staphylococcus aureus is a major human and animal pathogen, responsible for high levels of morbidity and mortality worldwide. The intracellular survival of S. aureus in macrophages contributes to immune evasion, dissemination, and resilience to antibiotic treatment. Here, we present a confocal fluorescence imaging assay for monitoring macrophage infection by green fluorescent protein (GFP)-tagged S. aureus as a front-line tool to identify antibiotic leads. The assay was employed in combination with nanoscaled chemical analyses to facilitate the discovery of a new, active rifamycin analogue. Our findings indicate a promising new approach for the identification of antimicrobial compounds with macrophage intracellular activity. The antibiotic identified here may represent a useful addition to our armory in tackling the silent pandemic of antimicrobial resistance." @default.
- W4383894987 created "2023-07-12" @default.
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- W4383894987 date "2023-07-11" @default.
- W4383894987 modified "2023-10-14" @default.
- W4383894987 title "Nanoscaled Discovery of a Shunt Rifamycin from <i>Salinispora arenicola</i> Using a Three-Color GFP-Tagged <i>Staphylococcus aureus</i> Macrophage Infection Assay" @default.
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- W4383894987 doi "https://doi.org/10.1021/acsinfecdis.3c00049" @default.
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