Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383896229> ?p ?o ?g. }
- W4383896229 endingPage "112803" @default.
- W4383896229 startingPage "112803" @default.
- W4383896229 abstract "During mouse embryogenesis, expression of the long non-coding RNA (lncRNA) Airn leads to gene repression and recruitment of Polycomb repressive complexes (PRCs) to varying extents over a 15-Mb domain. The mechanisms remain unclear. Using high-resolution approaches, we show in mouse trophoblast stem cells that Airn expression induces long-range changes to chromatin architecture that coincide with PRC-directed modifications and center around CpG island promoters that contact the Airn locus even in the absence of Airn expression. Intensity of contact between the Airn lncRNA and chromatin correlated with underlying intensity of PRC recruitment and PRC-directed modifications. Deletion of CpG islands that contact the Airn locus altered long-distance repression and PRC activity in a manner that correlated with changes in chromatin architecture. Our data imply that the extent to which Airn expression recruits PRCs to chromatin is controlled by DNA regulatory elements that modulate proximity of the Airn lncRNA product to its target DNA." @default.
- W4383896229 created "2023-07-12" @default.
- W4383896229 creator A5004683234 @default.
- W4383896229 creator A5005038887 @default.
- W4383896229 creator A5010223887 @default.
- W4383896229 creator A5014510120 @default.
- W4383896229 creator A5017918846 @default.
- W4383896229 creator A5021874905 @default.
- W4383896229 creator A5022264639 @default.
- W4383896229 creator A5056766982 @default.
- W4383896229 creator A5066761237 @default.
- W4383896229 date "2023-07-01" @default.
- W4383896229 modified "2023-10-15" @default.
- W4383896229 title "Proximity-dependent recruitment of Polycomb repressive complexes by the lncRNA Airn" @default.
- W4383896229 cites W122424169 @default.
- W4383896229 cites W1964789204 @default.
- W4383896229 cites W1972717887 @default.
- W4383896229 cites W1973062929 @default.
- W4383896229 cites W2001206796 @default.
- W4383896229 cites W2004966039 @default.
- W4383896229 cites W2005501593 @default.
- W4383896229 cites W2024800350 @default.
- W4383896229 cites W2025797510 @default.
- W4383896229 cites W2031896201 @default.
- W4383896229 cites W2040751058 @default.
- W4383896229 cites W2049137252 @default.
- W4383896229 cites W2053021469 @default.
- W4383896229 cites W2075846725 @default.
- W4383896229 cites W2077561581 @default.
- W4383896229 cites W2083736279 @default.
- W4383896229 cites W2090037139 @default.
- W4383896229 cites W2102619694 @default.
- W4383896229 cites W2108234281 @default.
- W4383896229 cites W2138207763 @default.
- W4383896229 cites W2153133532 @default.
- W4383896229 cites W2153301039 @default.
- W4383896229 cites W2155630480 @default.
- W4383896229 cites W2164773184 @default.
- W4383896229 cites W2169456326 @default.
- W4383896229 cites W2170551349 @default.
- W4383896229 cites W2171808845 @default.
- W4383896229 cites W2481029670 @default.
- W4383896229 cites W2493763501 @default.
- W4383896229 cites W2624274298 @default.
- W4383896229 cites W2745613569 @default.
- W4383896229 cites W2765567136 @default.
- W4383896229 cites W2765865112 @default.
- W4383896229 cites W2794011557 @default.
- W4383896229 cites W2796080638 @default.
- W4383896229 cites W2803479625 @default.
- W4383896229 cites W2807993805 @default.
- W4383896229 cites W2893751315 @default.
- W4383896229 cites W2908571759 @default.
- W4383896229 cites W2917748296 @default.
- W4383896229 cites W2918443914 @default.
- W4383896229 cites W2921653064 @default.
- W4383896229 cites W2951322997 @default.
- W4383896229 cites W2952044849 @default.
- W4383896229 cites W2954763649 @default.
- W4383896229 cites W2964212958 @default.
- W4383896229 cites W2970210543 @default.
- W4383896229 cites W2994756760 @default.
- W4383896229 cites W2997518667 @default.
- W4383896229 cites W3000068022 @default.
- W4383896229 cites W3010189944 @default.
- W4383896229 cites W3015659981 @default.
- W4383896229 cites W3027849952 @default.
- W4383896229 cites W3045805366 @default.
- W4383896229 cites W3047534747 @default.
- W4383896229 cites W3111061871 @default.
- W4383896229 cites W3115880421 @default.
- W4383896229 cites W3124680305 @default.
- W4383896229 cites W3139001257 @default.
- W4383896229 cites W3154328984 @default.
- W4383896229 cites W3191794308 @default.
- W4383896229 cites W3193447048 @default.
- W4383896229 cites W3200376887 @default.
- W4383896229 cites W3203089164 @default.
- W4383896229 cites W3208379306 @default.
- W4383896229 cites W3208459100 @default.
- W4383896229 cites W3212560957 @default.
- W4383896229 cites W35481948 @default.
- W4383896229 cites W4221137519 @default.
- W4383896229 cites W4225259708 @default.
- W4383896229 cites W4225386909 @default.
- W4383896229 cites W4281563303 @default.
- W4383896229 cites W4282915079 @default.
- W4383896229 doi "https://doi.org/10.1016/j.celrep.2023.112803" @default.
- W4383896229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37436897" @default.
- W4383896229 hasPublicationYear "2023" @default.
- W4383896229 type Work @default.
- W4383896229 citedByCount "0" @default.
- W4383896229 crossrefType "journal-article" @default.
- W4383896229 hasAuthorship W4383896229A5004683234 @default.
- W4383896229 hasAuthorship W4383896229A5005038887 @default.
- W4383896229 hasAuthorship W4383896229A5010223887 @default.
- W4383896229 hasAuthorship W4383896229A5014510120 @default.
- W4383896229 hasAuthorship W4383896229A5017918846 @default.