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- W4383896237 endingPage "112785" @default.
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- W4383896237 abstract "Peripheral inflammation has been linked to various neurodegenerative disorders, including Alzheimer’s disease (AD). Here we perform bulk, single-cell, and spatial transcriptomics in APP/PS1 mice intranasally exposed to Staphylococcus aureus to determine how low-grade peripheral infection affects brain transcriptomics and AD-like pathology. Chronic exposure led to increased amyloid plaque burden and plaque-associated microglia, significantly affecting the transcription of brain barrier-associated cells, which resulted in barrier leakage. We reveal cell-type- and spatial-specific transcriptional changes related to brain barrier function and neuroinflammation during the acute infection. Both acute and chronic exposure led to brain macrophage-associated responses and detrimental effects in neuronal transcriptomics. Finally, we identify unique transcriptional responses at the amyloid plaque niches following acute infection characterized by higher disease-associated microglia gene expression and a larger effect on astrocytic or macrophage-associated genes, which could facilitate amyloid and related pathologies. Our findings provide important insights into the mechanisms linking peripheral inflammation to AD pathology." @default.
- W4383896237 created "2023-07-12" @default.
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- W4383896237 date "2023-07-01" @default.
- W4383896237 modified "2023-10-17" @default.
- W4383896237 title "Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer’s disease model mice" @default.
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- W4383896237 doi "https://doi.org/10.1016/j.celrep.2023.112785" @default.
- W4383896237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37436901" @default.
- W4383896237 hasPublicationYear "2023" @default.