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- W4383896704 abstract "The aims of this study were to evaluate gastrointestinal (GI) retention of an ingested meal by fluorescence imaging and to compare how retention is affected by differences in the physical characteristics of meals. 1) Mice were orally given a fluorescent probe of indocyanine green (ICG) enclosed in a liposome, and then the correlation between abdominal and GI fluorescence signals was evaluated. 2) ICG was administered to mice treated with atropine, and abdominal fluorescence was observed repeatedly. 3) Mice were continuously given a regular chow diet or a liquid diet containing a low or high methoxyl (LM or HM)-pectin through a catheter placed in the stomach for 2 days, after which the mice were given ICG. In all studies, abdominal and GI fluorescence signals of the mice were observed with in vivo imaging equipment. 1) The fluorescence intensities (FIs) of the abdomen and the excised GI tract correlated strongly. 2) Attenuation of abdominal FI was delayed in the atropine-treatment group compared to the non-treatment group. 3) The attenuation of abdominal FI 8 to 24 h after ICG administration was significantly weakened in the HM group compared with the regular chow and LM groups. Observation of FI attenuation around the abdomen allows evaluation of GI tract retention of an ingested meal. Compared to a solid meal, a liquid meal stays longer in the digestive tract, whereas a liquid meal in which the viscosity increases in the stomach is retained in the same way as a solid meal." @default.
- W4383896704 created "2023-07-12" @default.
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- W4383896704 date "2023-12-01" @default.
- W4383896704 modified "2023-10-16" @default.
- W4383896704 title "Fluorescence imaging around the abdomen allows evaluation of gastrointestinal retention of various forms of diet in mice" @default.
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- W4383896704 doi "https://doi.org/10.1016/j.nut.2023.112162" @default.
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