FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383903822> ?p ?o ?g. }

• W4383903822 endingPage "322612" @default.
• W4383903822 startingPage "heartjnl" @default.
• W4383903822 abstract "Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disease characterised by fibrofatty replacement of the ventricular myocardium due to specific mutations, leading to ventricular arrhythmias and sudden cardiac death. Treating this condition can be challenging due to progressive fibrosis, phenotypic variations and small patient cohorts limiting the feasibility of conducting meaningful clinical trials. Although widely used, the evidence base for anti-arrhythmic drugs is limited. Beta-blockers are theoretically sound, yet their efficacy in reducing arrhythmic risk is not robust. Additionally, the impact of sotalol and amiodarone is inconsistent with studies reporting contradictory results. Emerging evidence suggests that combining flecainide and bisoprolol may be efficacious. Radiofrequency ablation has shown some potential in disrupting ventricular tachycardia circuits, with combined endo and epicardial ablation yielding better results which could be considered at the index procedure. In addition, stereotactic radiotherapy may be a future option that can decrease arrhythmias beyond simple scar formation by altering levels of Nav1.5 channels, Connexin 43 and Wnt signalling, potentially modifying myocardial fibrosis. Future therapies, such as adenoviruses and GSk3b modulation, are still in early-stage research. While implantable cardioverter-defibrillator implantation is a key intervention for reducing arrhythmic death, the risks of inappropriate shocks and device complications must be carefully considered." @default.
• W4383903822 created "2023-07-12" @default.
• W4383903822 creator A5006211041 @default.
• W4383903822 creator A5024316919 @default.
• W4383903822 creator A5038518412 @default.
• W4383903822 creator A5045352774 @default.
• W4383903822 date "2023-07-11" @default.
• W4383903822 modified "2023-09-25" @default.
• W4383903822 title "Management of arrhythmogenic right ventricular cardiomyopathy" @default.
• W4383903822 cites W1592800897 @default.
• W4383903822 cites W1673267543 @default.
• W4383903822 cites W1864092193 @default.
• W4383903822 cites W1876567013 @default.
• W4383903822 cites W1889753357 @default.
• W4383903822 cites W1972730332 @default.
• W4383903822 cites W1977859104 @default.
• W4383903822 cites W1983486304 @default.
• W4383903822 cites W1990649599 @default.
• W4383903822 cites W2112091653 @default.
• W4383903822 cites W2112500498 @default.
• W4383903822 cites W2125542173 @default.
• W4383903822 cites W2134740652 @default.
• W4383903822 cites W2138839726 @default.
• W4383903822 cites W2146807475 @default.
• W4383903822 cites W2166297399 @default.
• W4383903822 cites W2341491381 @default.
• W4383903822 cites W2347068500 @default.
• W4383903822 cites W2559851768 @default.
• W4383903822 cites W2560432682 @default.
• W4383903822 cites W2592043926 @default.
• W4383903822 cites W2623904994 @default.
• W4383903822 cites W2736049462 @default.
• W4383903822 cites W2771630528 @default.
• W4383903822 cites W2808013948 @default.
• W4383903822 cites W2899649250 @default.
• W4383903822 cites W2902849677 @default.
• W4383903822 cites W2904305388 @default.
• W4383903822 cites W2908559178 @default.
• W4383903822 cites W2913579958 @default.
• W4383903822 cites W3031483955 @default.
• W4383903822 cites W3034614380 @default.
• W4383903822 cites W3091847721 @default.
• W4383903822 cites W3112353255 @default.
• W4383903822 cites W3158135066 @default.
• W4383903822 cites W3158247648 @default.
• W4383903822 cites W3162067732 @default.
• W4383903822 cites W3199730338 @default.
• W4383903822 cites W3204557170 @default.
• W4383903822 cites W3215795069 @default.
• W4383903822 cites W3216383239 @default.
• W4383903822 cites W4212769541 @default.
• W4383903822 cites W4225699182 @default.
• W4383903822 cites W4225753788 @default.
• W4383903822 cites W4283715095 @default.
• W4383903822 cites W4295430541 @default.
• W4383903822 cites W4323569626 @default.
• W4383903822 cites W4377015992 @default.
• W4383903822 doi "https://doi.org/10.1136/heartjnl-2023-322612" @default.
• W4383903822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37433658" @default.
• W4383903822 hasPublicationYear "2023" @default.
• W4383903822 type Work @default.
• W4383903822 citedByCount "0" @default.
• W4383903822 crossrefType "journal-article" @default.
• W4383903822 hasAuthorship W4383903822A5006211041 @default.
• W4383903822 hasAuthorship W4383903822A5024316919 @default.
• W4383903822 hasAuthorship W4383903822A5038518412 @default.
• W4383903822 hasAuthorship W4383903822A5045352774 @default.
• W4383903822 hasConcept C126322002 @default.
• W4383903822 hasConcept C164705383 @default.
• W4383903822 hasConcept C2775935837 @default.
• W4383903822 hasConcept C2776131983 @default.
• W4383903822 hasConcept C2776331378 @default.
• W4383903822 hasConcept C2776639339 @default.
• W4383903822 hasConcept C2777377203 @default.
• W4383903822 hasConcept C2778094803 @default.
• W4383903822 hasConcept C2778198053 @default.
• W4383903822 hasConcept C2778797674 @default.
• W4383903822 hasConcept C2778902805 @default.
• W4383903822 hasConcept C2779161974 @default.
• W4383903822 hasConcept C2779837460 @default.
• W4383903822 hasConcept C71924100 @default.
• W4383903822 hasConceptScore W4383903822C126322002 @default.
• W4383903822 hasConceptScore W4383903822C164705383 @default.
• W4383903822 hasConceptScore W4383903822C2775935837 @default.
• W4383903822 hasConceptScore W4383903822C2776131983 @default.
• W4383903822 hasConceptScore W4383903822C2776331378 @default.
• W4383903822 hasConceptScore W4383903822C2776639339 @default.
• W4383903822 hasConceptScore W4383903822C2777377203 @default.
• W4383903822 hasConceptScore W4383903822C2778094803 @default.
• W4383903822 hasConceptScore W4383903822C2778198053 @default.
• W4383903822 hasConceptScore W4383903822C2778797674 @default.
• W4383903822 hasConceptScore W4383903822C2778902805 @default.
• W4383903822 hasConceptScore W4383903822C2779161974 @default.
• W4383903822 hasConceptScore W4383903822C2779837460 @default.
• W4383903822 hasConceptScore W4383903822C71924100 @default.
• W4383903822 hasFunder F4320319992 @default.
• W4383903822 hasLocation W43839038221 @default.
• W4383903822 hasLocation W43839038222 @default.

• next