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Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383903833> ?p ?o ?g. }

• W4383903833 endingPage "020495" @default.
• W4383903833 startingPage "jnis" @default.
• W4383903833 abstract "The optimal duration of dual antiplatelet therapy (DAPT) in patients with cerebral aneurysm who undergo stent-assisted coil embolization (SACE) has not been established. We aimed to clarify the association between duration of DAPT and incidence of ischemic stroke in patients with cerebral aneurysm.We registered patients with cerebral aneurysm who underwent SACE in 27 hospitals in Japan. Those treated with DAPT (aspirin and clopidogrel) were eligible for inclusion in a previously reported randomized control trial (RCT). Patients who were ineligible or refused to participate to the RCT were followed-up for 15 months after SACE as the non-RCT cohort. Our study examined both the RCT and non-RCT cohorts. The primary and secondary outcomes were ischemic stroke and hemorrhagic events.Among the 313 patients registered, 296 were included for analysis (of these, 136 were RCT patients and 160 were non-RCT patients). Patients who were treated with DAPT for more than 6 months (n=191) were classified as the long-term DAPT group. Those treated less than 6 months (n=105) were classified as the short-term group. The incidence of ischemic stroke did not significantly differ between the long-term group (2.5 per 100 person-years) and the short-term group (3.2 per 100 person-years); nor did incidence of hemorrhagic events (0.8 and 3.2 per 100 person-years, respectively). The period of DAPT was not significantly associated with incidence rates of ischemic stroke or hemorrhagic events.Duration of DAPT was not associated with the incidence of ischemic stroke in the first 15 months after SACE." @default.
• W4383903833 created "2023-07-12" @default.
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• W4383903833 date "2023-07-11" @default.
• W4383903833 modified "2023-10-02" @default.
• W4383903833 title "Relation between duration of dual antiplatelet therapy and risk of ischemic stroke after stent-assisted treatment of cerebral aneurysm (DAPTS ACE-registry)" @default.
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• W4383903833 doi "https://doi.org/10.1136/jnis-2023-020495" @default.
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