Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383907887> ?p ?o ?g. }
- W4383907887 abstract "Abstract A gas chromatography-mass spectrometry (GC–MS) method for the determination of difenidol hydrochloride in biological specimens has been developed. The method exhibited excellent recovery (> 90%) and precision (RSD < 10%), and the LOD was 0.05 μg/mL or μg/g, which met the requirements of bioanalytical method. Through the animal model of the forensic toxicokinetics, the dynamic distribution, postmortem redistribution (PMR) and stability in specimen preservation process of difenidol in animals were studied. The experimental results showed that after intragastric administration, the difenidol’s concentrations in the heart-blood and various organs increased over time except stomach, and then decreased gradually after reaching the peaks of concentration. The toxicological kinetics equation and toxicokinetic parameters were established by processing the data of the mean drug concentration of difenidol changing with time. In PMR experiment, the concentrations of difenidol in some organs closer to the gastrointestinal tract (heart-blood, heart, liver, lung, kidney, and spleen) changed significantly at different time points. But the concentration of difenidol in brain tissues which were far away from the gastrointestinal tract and muscles with larger overall mass was relatively stable. PMR of difenidol was therefore confirmed. Thus, the effect of PMR on the concentration of difenidol in the specimens should be considered in cases involving difenidol poisoning or death. Furthermore, the stability of difenidol in heart-blood samples from poisoned rats was investigated at various time points and under different preservation conditions (20 °C, 4 °C, − 20 °C and 20 °C (1% NaF)) for a period of two months. Difenidol was stable and did not decompose in the preserved blood. Therefore, this study provided the experimental basis for the forensic identification of the cases of difenidol hydrochloride poisoning (death). PMR has been verified by practical lethal cases." @default.
- W4383907887 created "2023-07-12" @default.
- W4383907887 creator A5002710972 @default.
- W4383907887 creator A5014332952 @default.
- W4383907887 creator A5032073558 @default.
- W4383907887 creator A5035989132 @default.
- W4383907887 creator A5038725556 @default.
- W4383907887 creator A5066805359 @default.
- W4383907887 creator A5078508325 @default.
- W4383907887 creator A5080456024 @default.
- W4383907887 creator A5082974532 @default.
- W4383907887 creator A5089078063 @default.
- W4383907887 creator A5089966579 @default.
- W4383907887 date "2023-07-11" @default.
- W4383907887 modified "2023-10-15" @default.
- W4383907887 title "Forensic toxicokinetics of difenidol hydrochloride in vivo verified by practical lethal cases" @default.
- W4383907887 cites W1575712167 @default.
- W4383907887 cites W1579472385 @default.
- W4383907887 cites W2015979877 @default.
- W4383907887 cites W2079788026 @default.
- W4383907887 cites W2086939060 @default.
- W4383907887 cites W2112230867 @default.
- W4383907887 cites W2146309768 @default.
- W4383907887 cites W2150712712 @default.
- W4383907887 cites W2160391909 @default.
- W4383907887 cites W2164269016 @default.
- W4383907887 cites W2171707152 @default.
- W4383907887 cites W2410887930 @default.
- W4383907887 cites W2645129152 @default.
- W4383907887 cites W2713565928 @default.
- W4383907887 cites W3032869611 @default.
- W4383907887 cites W3092085932 @default.
- W4383907887 cites W33897432 @default.
- W4383907887 cites W4246723846 @default.
- W4383907887 cites W4254185355 @default.
- W4383907887 cites W75171083 @default.
- W4383907887 doi "https://doi.org/10.1038/s41598-023-38246-y" @default.
- W4383907887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37433899" @default.
- W4383907887 hasPublicationYear "2023" @default.
- W4383907887 type Work @default.
- W4383907887 citedByCount "0" @default.
- W4383907887 crossrefType "journal-article" @default.
- W4383907887 hasAuthorship W4383907887A5002710972 @default.
- W4383907887 hasAuthorship W4383907887A5014332952 @default.
- W4383907887 hasAuthorship W4383907887A5032073558 @default.
- W4383907887 hasAuthorship W4383907887A5035989132 @default.
- W4383907887 hasAuthorship W4383907887A5038725556 @default.
- W4383907887 hasAuthorship W4383907887A5066805359 @default.
- W4383907887 hasAuthorship W4383907887A5078508325 @default.
- W4383907887 hasAuthorship W4383907887A5080456024 @default.
- W4383907887 hasAuthorship W4383907887A5082974532 @default.
- W4383907887 hasAuthorship W4383907887A5089078063 @default.
- W4383907887 hasAuthorship W4383907887A5089966579 @default.
- W4383907887 hasBestOaLocation W43839078871 @default.
- W4383907887 hasConcept C112705442 @default.
- W4383907887 hasConcept C126322002 @default.
- W4383907887 hasConcept C150903083 @default.
- W4383907887 hasConcept C158342456 @default.
- W4383907887 hasConcept C185592680 @default.
- W4383907887 hasConcept C195289149 @default.
- W4383907887 hasConcept C207001950 @default.
- W4383907887 hasConcept C2779422922 @default.
- W4383907887 hasConcept C2780091579 @default.
- W4383907887 hasConcept C2780512811 @default.
- W4383907887 hasConcept C2780931953 @default.
- W4383907887 hasConcept C3020580990 @default.
- W4383907887 hasConcept C43617362 @default.
- W4383907887 hasConcept C55493867 @default.
- W4383907887 hasConcept C71924100 @default.
- W4383907887 hasConcept C86803240 @default.
- W4383907887 hasConcept C98274493 @default.
- W4383907887 hasConceptScore W4383907887C112705442 @default.
- W4383907887 hasConceptScore W4383907887C126322002 @default.
- W4383907887 hasConceptScore W4383907887C150903083 @default.
- W4383907887 hasConceptScore W4383907887C158342456 @default.
- W4383907887 hasConceptScore W4383907887C185592680 @default.
- W4383907887 hasConceptScore W4383907887C195289149 @default.
- W4383907887 hasConceptScore W4383907887C207001950 @default.
- W4383907887 hasConceptScore W4383907887C2779422922 @default.
- W4383907887 hasConceptScore W4383907887C2780091579 @default.
- W4383907887 hasConceptScore W4383907887C2780512811 @default.
- W4383907887 hasConceptScore W4383907887C2780931953 @default.
- W4383907887 hasConceptScore W4383907887C3020580990 @default.
- W4383907887 hasConceptScore W4383907887C43617362 @default.
- W4383907887 hasConceptScore W4383907887C55493867 @default.
- W4383907887 hasConceptScore W4383907887C71924100 @default.
- W4383907887 hasConceptScore W4383907887C86803240 @default.
- W4383907887 hasConceptScore W4383907887C98274493 @default.
- W4383907887 hasFunder F4320321001 @default.
- W4383907887 hasIssue "1" @default.
- W4383907887 hasLocation W43839078871 @default.
- W4383907887 hasLocation W43839078872 @default.
- W4383907887 hasLocation W43839078873 @default.
- W4383907887 hasOpenAccess W4383907887 @default.
- W4383907887 hasPrimaryLocation W43839078871 @default.
- W4383907887 hasRelatedWork W1491964893 @default.
- W4383907887 hasRelatedWork W2004556784 @default.
- W4383907887 hasRelatedWork W2086209760 @default.
- W4383907887 hasRelatedWork W2094219250 @default.
- W4383907887 hasRelatedWork W2167332331 @default.