FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383912485> ?p ?o ?g. }

• W4383912485 endingPage "11284" @default.
• W4383912485 startingPage "11284" @default.
• W4383912485 abstract "Patients with obstructive sleep apnea (OSA) exhibit a high prevalence of pulmonary hypertension and right ventricular (RV) hypertrophy. However, the exact molecule responsible for the pathogenesis remains unknown. Given the resistance to RV dilation observed in transient receptor potential canonical 3(Trpc3)-/- mice during a pulmonary hypertension model induced by phenylephrine (PE), we hypothesized that TRPC3 also plays a role in chronic intermittent hypoxia (CIH) conditions, which lead to RV dilation and dysfunction. To test this, we established an OSA mouse model using 8- to 12-week-old 129/SvEv wild-type and Trpc3-/- mice in a customized breeding chamber that simulated sleep and oxygen cycles. Functional parameters of the RV were evaluated through analysis of cardiac cine magnetic resonance images, while histopathological examinations were conducted on cardiomyocytes and pulmonary vessels. Following exposure to 4 weeks of CIH, Trpc3-/- mice exhibited significant RV dysfunction, characterized by decreased ejection fraction, increased end-diastole RV wall thickness, and elevated expression of pathological cardiac markers. In addition, reactive oxygen species (ROS) signaling and the endothelin system were markedly increased solely in the hearts of CIH-exposed Trpc3-/- mice. Notably, no significant differences in pulmonary vessel thickness or the endothelin system were observed in the lungs of wild-type (WT) and Trpc3-/- mice subjected to 4 weeks of CIH. In conclusion, our findings suggest that TRPC3 serves as a regulator of RV resistance in response to pressure from the pulmonary vasculature, as evidenced by the high susceptibility to RV dilation in Trpc3-/- mice without notable changes in pulmonary vasculature under CIH conditions." @default.
• W4383912485 created "2023-07-12" @default.
• W4383912485 creator A5003363567 @default.
• W4383912485 creator A5018365943 @default.
• W4383912485 creator A5021649737 @default.
• W4383912485 creator A5026859102 @default.
• W4383912485 creator A5034043684 @default.
• W4383912485 creator A5049337478 @default.
• W4383912485 creator A5059086827 @default.
• W4383912485 creator A5067200067 @default.
• W4383912485 creator A5076754112 @default.
• W4383912485 date "2023-07-10" @default.
• W4383912485 modified "2023-10-14" @default.
• W4383912485 title "Role of TRPC3 in Right Ventricular Dilatation under Chronic Intermittent Hypoxia in 129/SvEv Mice" @default.
• W4383912485 cites W1976398898 @default.
• W4383912485 cites W1978581576 @default.
• W4383912485 cites W1986866353 @default.
• W4383912485 cites W1986915601 @default.
• W4383912485 cites W1989647827 @default.
• W4383912485 cites W1991131183 @default.
• W4383912485 cites W2002270306 @default.
• W4383912485 cites W2003055862 @default.
• W4383912485 cites W2003340858 @default.
• W4383912485 cites W2011477996 @default.
• W4383912485 cites W2011785006 @default.
• W4383912485 cites W2014947245 @default.
• W4383912485 cites W2034556696 @default.
• W4383912485 cites W2043072729 @default.
• W4383912485 cites W2074461681 @default.
• W4383912485 cites W2076641973 @default.
• W4383912485 cites W2078669850 @default.
• W4383912485 cites W2092072311 @default.
• W4383912485 cites W2092352619 @default.
• W4383912485 cites W2093943199 @default.
• W4383912485 cites W2124052130 @default.
• W4383912485 cites W2130961266 @default.
• W4383912485 cites W2134966197 @default.
• W4383912485 cites W2139356364 @default.
• W4383912485 cites W2156433522 @default.
• W4383912485 cites W2161561494 @default.
• W4383912485 cites W2167151063 @default.
• W4383912485 cites W2441644746 @default.
• W4383912485 cites W2516068096 @default.
• W4383912485 cites W2550260944 @default.
• W4383912485 cites W2621496307 @default.
• W4383912485 cites W2737485346 @default.
• W4383912485 cites W2741818457 @default.
• W4383912485 cites W2772891875 @default.
• W4383912485 cites W2904740860 @default.
• W4383912485 cites W2910667490 @default.
• W4383912485 cites W3025606242 @default.
• W4383912485 cites W4210343616 @default.
• W4383912485 cites W4224437039 @default.
• W4383912485 doi "https://doi.org/10.3390/ijms241411284" @default.
• W4383912485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37511045" @default.
• W4383912485 hasPublicationYear "2023" @default.
• W4383912485 type Work @default.
• W4383912485 citedByCount "0" @default.
• W4383912485 crossrefType "journal-article" @default.
• W4383912485 hasAuthorship W4383912485A5003363567 @default.
• W4383912485 hasAuthorship W4383912485A5018365943 @default.
• W4383912485 hasAuthorship W4383912485A5021649737 @default.
• W4383912485 hasAuthorship W4383912485A5026859102 @default.
• W4383912485 hasAuthorship W4383912485A5034043684 @default.
• W4383912485 hasAuthorship W4383912485A5049337478 @default.
• W4383912485 hasAuthorship W4383912485A5059086827 @default.
• W4383912485 hasAuthorship W4383912485A5067200067 @default.
• W4383912485 hasAuthorship W4383912485A5076754112 @default.
• W4383912485 hasBestOaLocation W43839124851 @default.
• W4383912485 hasConcept C126322002 @default.
• W4383912485 hasConcept C134018914 @default.
• W4383912485 hasConcept C149601957 @default.
• W4383912485 hasConcept C155164980 @default.
• W4383912485 hasConcept C164705383 @default.
• W4383912485 hasConcept C170488646 @default.
• W4383912485 hasConcept C170493617 @default.
• W4383912485 hasConcept C178790620 @default.
• W4383912485 hasConcept C185592680 @default.
• W4383912485 hasConcept C2779376020 @default.
• W4383912485 hasConcept C2780383360 @default.
• W4383912485 hasConcept C2780930700 @default.
• W4383912485 hasConcept C540031477 @default.
• W4383912485 hasConcept C71924100 @default.
• W4383912485 hasConcept C7836513 @default.
• W4383912485 hasConceptScore W4383912485C126322002 @default.
• W4383912485 hasConceptScore W4383912485C134018914 @default.
• W4383912485 hasConceptScore W4383912485C149601957 @default.
• W4383912485 hasConceptScore W4383912485C155164980 @default.
• W4383912485 hasConceptScore W4383912485C164705383 @default.
• W4383912485 hasConceptScore W4383912485C170488646 @default.
• W4383912485 hasConceptScore W4383912485C170493617 @default.
• W4383912485 hasConceptScore W4383912485C178790620 @default.
• W4383912485 hasConceptScore W4383912485C185592680 @default.
• W4383912485 hasConceptScore W4383912485C2779376020 @default.
• W4383912485 hasConceptScore W4383912485C2780383360 @default.
• W4383912485 hasConceptScore W4383912485C2780930700 @default.
• W4383912485 hasConceptScore W4383912485C540031477 @default.
• W4383912485 hasConceptScore W4383912485C71924100 @default.

• next