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- W4383957246 abstract "Autoimmune diseases (ADs) are characterized by the production of autoreactive lymphocytes, immune responses to self-antigens, and inflammation in related tissues and organs. Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is majorly expressed in activated T cells and works as a critical regulator in the inflammatory response. In this review, we first describe the structure, expression, and how the signaling pathways of CTLA-4 participate in reducing effector T-cell activity and enhancing the immunomodulatory ability of regulatory T (Treg) cells to reduce immune response, maintain immune homeostasis, and maintain autoimmune silence. We then focused on the correlation between CTLA-4 and different ADs and how this molecule regulates the immune activity of the diseases and inhibits the onset, progression, and pathology of various ADs. Finally, we summarized the current progress of CTLA-4 as a therapeutic target for various ADs." @default.
- W4383957246 created "2023-07-12" @default.
- W4383957246 creator A5010719742 @default.
- W4383957246 creator A5021424244 @default.
- W4383957246 creator A5021589387 @default.
- W4383957246 creator A5023581100 @default.
- W4383957246 creator A5023597320 @default.
- W4383957246 creator A5043460699 @default.
- W4383957246 creator A5051898409 @default.
- W4383957246 creator A5074300225 @default.
- W4383957246 creator A5085684152 @default.
- W4383957246 date "2023-07-11" @default.
- W4383957246 modified "2023-10-14" @default.
- W4383957246 title "Current understanding of CTLA-4: from mechanism to autoimmune diseases" @default.
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