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- W4383958570 abstract "Patients suffering from diabetes rely on the exogenous supply of insulin. Cell replacement therapy employing cadaveric islets cells has demonstrated a proof of principle for a practical cure, rendering patients insulin independent for prolonged periods of time. However, challenges remain before this innovative therapy can be widely accessed by patients in need. Donor islet material is limited, requiring the generation of an abundant source of insulin-producing pancreatic beta cells. Immunological allogeneic rejection and recurring autoreactivity contribute to eventual graft failure in all transplant recipients. Here we summarize past and current efforts to generate functional beta cells from pluripotent stem cells and highlight current knowledge on graft immune interactions. We further discuss remaining challenges of current cell replacement efforts and highlight potentially innovative approaches to aid current strategies." @default.
- W4383958570 created "2023-07-12" @default.
- W4383958570 creator A5010026876 @default.
- W4383958570 creator A5014701275 @default.
- W4383958570 date "2023-04-18" @default.
- W4383958570 modified "2023-10-02" @default.
- W4383958570 title "Stem cell-derived pancreatic beta cells for the study and treatment of diabetes" @default.
- W4383958570 cites W1549484347 @default.
- W4383958570 cites W1574138266 @default.
- W4383958570 cites W1811184783 @default.
- W4383958570 cites W1970910239 @default.
- W4383958570 cites W1974609577 @default.
- W4383958570 cites W1981374189 @default.
- W4383958570 cites W1984697722 @default.
- W4383958570 cites W1992841988 @default.
- W4383958570 cites W1996932943 @default.
- W4383958570 cites W2013438463 @default.
- W4383958570 cites W2016127324 @default.
- W4383958570 cites W2032472678 @default.
- W4383958570 cites W2038404321 @default.
- W4383958570 cites W2041515126 @default.
- W4383958570 cites W2044025778 @default.
- W4383958570 cites W2047359339 @default.
- W4383958570 cites W2048438191 @default.
- W4383958570 cites W2050480410 @default.
- W4383958570 cites W2050977906 @default.
- W4383958570 cites W2055001415 @default.
- W4383958570 cites W2072977775 @default.
- W4383958570 cites W2081794370 @default.
- W4383958570 cites W2086943348 @default.
- W4383958570 cites W2091618147 @default.
- W4383958570 cites W2096261947 @default.
- W4383958570 cites W2106219965 @default.
- W4383958570 cites W2111347392 @default.
- W4383958570 cites W2112558600 @default.
- W4383958570 cites W2118332672 @default.
- W4383958570 cites W2125987139 @default.
- W4383958570 cites W2137464815 @default.
- W4383958570 cites W2138977668 @default.
- W4383958570 cites W2142046859 @default.
- W4383958570 cites W2144155263 @default.
- W4383958570 cites W2148890861 @default.
- W4383958570 cites W2149130444 @default.
- W4383958570 cites W2150567837 @default.
- W4383958570 cites W2151897007 @default.
- W4383958570 cites W2165868396 @default.
- W4383958570 cites W2165996867 @default.
- W4383958570 cites W2168128391 @default.
- W4383958570 cites W2170781656 @default.
- W4383958570 cites W2171019508 @default.
- W4383958570 cites W2177631887 @default.
- W4383958570 cites W2262286634 @default.
- W4383958570 cites W2265806176 @default.
- W4383958570 cites W2328786770 @default.
- W4383958570 cites W2332910275 @default.
- W4383958570 cites W2381312419 @default.
- W4383958570 cites W2487303921 @default.
- W4383958570 cites W2577007969 @default.
- W4383958570 cites W2589143196 @default.
- W4383958570 cites W2616215756 @default.
- W4383958570 cites W2669889121 @default.
- W4383958570 cites W2760296413 @default.
- W4383958570 cites W2769764904 @default.
- W4383958570 cites W2775731768 @default.
- W4383958570 cites W2783137027 @default.
- W4383958570 cites W2786832994 @default.
- W4383958570 cites W2789379892 @default.
- W4383958570 cites W2791434134 @default.
- W4383958570 cites W2899044337 @default.
- W4383958570 cites W2903991851 @default.
- W4383958570 cites W2910245538 @default.
- W4383958570 cites W2911604931 @default.
- W4383958570 cites W2913837249 @default.
- W4383958570 cites W2915321625 @default.
- W4383958570 cites W2922044450 @default.
- W4383958570 cites W2943378944 @default.
- W4383958570 cites W2944418523 @default.
- W4383958570 cites W2944658035 @default.
- W4383958570 cites W2951530707 @default.
- W4383958570 cites W2989444224 @default.
- W4383958570 cites W3014961299 @default.
- W4383958570 cites W3018193307 @default.
- W4383958570 cites W3025013266 @default.
- W4383958570 cites W3025788478 @default.
- W4383958570 cites W3037977980 @default.
- W4383958570 cites W3068518905 @default.
- W4383958570 cites W3083963077 @default.
- W4383958570 cites W3116278714 @default.
- W4383958570 cites W3120974422 @default.
- W4383958570 cites W3126269290 @default.
- W4383958570 cites W3135366388 @default.
- W4383958570 cites W3138583964 @default.
- W4383958570 cites W3150249245 @default.
- W4383958570 cites W3155796259 @default.
- W4383958570 cites W3160669634 @default.
- W4383958570 cites W3180468548 @default.
- W4383958570 cites W3192787351 @default.
- W4383958570 cites W4214836757 @default.
- W4383958570 cites W4214950345 @default.
- W4383958570 cites W4220915289 @default.